Osteolysis in total hip arthroplasty in relation to metal ion release: Comparison between monolithic prostheses and different modularities

Table 1 Patients with monolithic total hip arthroplasty

Group A
Patient	Age	Cr serum (μg/L)	Cr urine (μg/L)	Co serum (μg/L)	Co urine (μg/L)
1	58	0.53	0.69	3.9	6
2	63	0.14	0	0	0.76
3	69	0.92	2.71	3.22	14.53
4	76	0.8	2.14	11.1	34.9
5	77	0.07	0.11	0.1	0.1
6	65	no	1.48	5.03	14.9
7	71	0.1	0.4	0.82	0.2
8	74	0.08	0.61	0.73	2.1
9	75	0.5	1.13	4.3	9.6
10	78	0.77	2.94	10.65	27.5
11	79	2.05	4.36	7.92	17.4
12	75	0.7	1.7	4.6	9.4
13	65	0.37	2.3	7.84	26
14	75	1.14	3.86	6.38	24.2
15	70	0.1	0.1	0.1	0.1
16	69	0.3	1.25	1.77	7.1
17	72	0.34	0.04	0.1	0
18	71	0.76	1.07	2.06	9.3
19	74	0.1	0.09	0.67	0.1
20	65	0.1	0.22	1.34	3.9
21	64	0.1	0.52	0.34	0.2
22	72	1.87	3.69	7.25	12.38
23	78	0.1	1.02	2.41	10.7
Mean	71.08	0.54	1.41	3.59	10.06
ST.DEV		0.56	1.33	3.46	10.19

Table 2 Patients with modular/ceramic head total hip harthroplasty

Group B
Patient	Age	Cr serum (μg/L)	Cr urine (μg/L)	Co serum (μg/L)	Co urine (μg/L)
24	68	1.56	3.9	4.19	19.2
25	71	0.1	2.34	2.09	21.15
26	69	0.38	1.59	2.3	15.2
27	70	0.67	1.91	0.61	0.2
28	71	2.25	7.52	5.6	17.7
29	75	0.77	2.36	6.33	19.5
30	55	0.44	1.55	3.76	19.9
31	74	0.53	1.9	3.4	23.9
32	76	0.55	1.94	2.95	29.4
33	74	0.18	0.24	1.83	4.7
34	69	0.11	1.54	0.85	0.2
35	81	0.2	1.28	1.79	2.1
36	78	0.5	0.49	3.93	12.5
37	65	0.38	3.89	1.44	12.4
38	74	1.03	2.59	6.28	26.4
39	79	0.73	3.19	2.55	4.7
40	72	0.35	1.57	1.93	16
41	73	0.24	0.78	2.19	5.3
42	55	1.13	1.97	1.93	7.2
43	71	0.1	1.41	0.46	27.2
44	77	1.96	3.48	3.63	24.4
Mean	71.28	0.67	2.34	3.05	14.42
ST.DEV		0.60	1.66	1.76	9.18

Table 3 Patients with modular/metallic head total hip arthroplasty

Group C
Patient	Age	Cr serum (μg/L)	Cr urine (μg/L)	Co serum (μg/L)	Co urine (μg/L)
45	84	1.78	4	7.02	27.7
46	73	0.9	4.89	9.8	28.9
47	67	2.19	8.4	5.1	19.1
48	73	0.27	2.56	4.43	24.9
49	69	1.26	5.04	8.56	40.1
50	68	0.26	0.8	3.01	15
51	73	0.32	3.18	3.2	18.2
52	74	0.1	1.96	2.7	3.5
53	62	0.84	2.96	3.5	12.3
54	79	0.81	3.27	4.45	19.7
55	71	0.55	2.72	3.86	18.6
56	78	2.5	1.9	5.22	14.8
57	73	0.84	1.99	0.46	7.5
58	59	1.31	3.8	4.77	25.3
59	75	0.19	2.99	4.03	22.5
60	59	0.39	0.88	0.76	7.89
61	74	0.9	3.5	4.56	24.7
62	52	0.55	0.98	5.55	19.8
63	64	0.7	2.21	4	14.5
64	85	0.59	7.19	5.72	41.6
65	72	1.94	4.69	7.14	41.9
66	77	0.15	1.94	2.17	16.1
67	71	0.1	1.58	1.33	7.9
68	72	1.4	3.57	8.84	35.4
69	85	1.24	2.07	13.78	60.2
70	32	2.65	1.77	7.03	16.7
71	79	1.27	3.28	2.09	18.2
72	79	0.84	1.7	4.52	17
73	74	0.96	3.89	15.47	36.8
74	60	0.14	1.05	4.94	11.16
75	79	0.49	2.41	1	6
76	78	0.75	1.5	7.22	18
Mean	70.93	0.91	2.95	5.29	21.73
ST.DEV		0.69	1.75	3.41	12.64

Table 4 Localization of osteolysis in peri-prosthetic field

	Group A	Group B	Group C
Site of osteolysis
Gruen zone 7	2	2	4
Gruen zone 1	2	6	12
DeLee zone 1 and 2	5	3	3

Table 5 For every group mean values of blood and urinal concentration of Chrom and Cobalt are related to cases of osteolysis

	Cr Serum (μg/L)	Cr urine (μg/L)	Co serum (μg/L)	Co urine (μg/L)	Cases of Gr. 2 osteolysis	Cases of Gr. 3 osteolysis
Group 1	0.54	1.41	3.59	10.06	2	0
Group 2	0.67	2.24	3.05	14.42	7	0
Group 3	0.91	2.95	5.29	21.73	9	3

Cr: Chrom; Co: Cobalt.