Rajkovic CJ, Merckling ML, Lee AW, Subah G, Malhotra A, Thomas ZD, Zeller SL, Wainwright JV, Kinon MD. Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature. World J Orthop 2024; 15(9): 870-881 [PMID: 39318497 DOI: 10.5312/wjo.v15.i9.870]
Reader's ID:
03071987
Submitted on:
September 12, 2024, 18:38
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Reader Comments:
The subject with autologous conditioned serum (ACS) as a therapeutic agent for spine pathology is very interesting and the outcomes from meta-analysis was great. Actually, the ACS method has not been widely used so far, so the kind of analysis could make it the feasibility and safety for spreading its use. However, the article has some minor limitations for the general use. Most of all, the articles used at the meta-analysis were made from duplicated institutes (just 3 different hospitals) and in the meta-analysis some statistical results were lacking, so it is hard to believe that the outcomes can be generalized. Nevertheless, the study has a strong point that only a few article have handled the ACS for confirming clinical effectiveness for spinal disease. Thus, the article can be a cornerstone of ACS use for spine pathology, and further studies regarding the ACS are necessary to greater define the effectiveness and safety.
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