Validation of methods to assess potential biomarkers in pediatric patients with esophageal eosinophilia

Figure 1 Sample evaluation. A: Tryptase staining for mast cells; B: Grade 0 major basic protein (MBP) involvement (none); C: Grade 1 MBP involvement (< 5%); D: Grade 2 MBP involvement (5%-25%); E: Grade 3 MBP involvement (> 25%); F: Trichrome staining for fibrosis.

Figure 2 Biomarker comparison between high eosinophil and low esophageal density. A: Comparison of mast cells reflux esophagitis (RE) vs eosinophilic esophagitis (EoE); B: Comparison of major basic protein (MBP) density RE vs EoE; C: Comparison of receiver operating characteristic (ROC) performance across mast cell and MBP density variables.