Depression risk in patients with coronary heart disease in Germany

Table 1 Characteristics of coronary heart disease patients and matched controls treated in primary care practices in Germany

Variables	CHD group	Control group	P value
n	59992	59992
Age (yr)	68.0 (11.3)	68.0 (11.3)	1
Aged ≤ 60 (%)	26.7	26.7	1
Aged 61-70 (%)	26.5	26.5	1
Aged 71-80 (%)	32.6	32.6	1
Aged > 80 (%)	14.3	14.3	1
Males (%)	55.9	55.9	1
Follow-up time (yr)	3.6 (1.5)	3.6 (1.5)	1
Past depression diagnosis (> 12 mo prior to index date)	11.1	11.1	1
Co-diagnosis (%)
Diabetes	35.9	23.4	< 0.001
Hypertension	78.7	59.4	< 0.001
Myocardial infarction	11.8	0.6	< 0.001
Cardiac arrhythmias	25.7	14.3	< 0.001
Heart failure	18.4	7.4	< 0.001
Stroke	9.2	5.6	< 0.001
Cancer	11.9	11.1	< 0.001
Dementia	4.9	4.5	< 0.001
Osteoarthritis	31.4	27.6	< 0.001
Osteoporosis	10.3	8.4	< 0.001

CHD: Coronary heart disease.

Table 2 Multivariate Cox regression model for depression diagnosis in coronary heart disease patients and matched controls chemotherapy

Variables	Hazard ratio (95%CI)	P value
CHD	1.54 (1.49-1.59)	< 0.001
Past depression diagnosis	3.44 (3.32-3.56)	< 0.001
Aged ≤ 60 vs 61-70	1.50 (1.44-1.57)	< 0.001
Aged 71-80 vs 61-70	1.08 (1.04-1.13)	< 0.001
Aged > 80 vs 61-70	1.16 (1.10-1.23)	< 0.001
Male gender	0.67 (0.65-0.69)	< 0.001
Dementia	1.24 (1.17-1.31)	< 0.001
Stroke	1.22 (1.16-1.28)	< 0.001
Cancer	1.19 (1.14-1.24)	< 0.001
Osteoporosis	1.18 (1.13-1.24)	< 0.001
Heart failure	1.17 (1.12-1.22)	< 0.001
Osteoarthritis	1.15 (1.11-1.19)	< 0.001
Hypertension	1.10 (1.06-1.14)	< 0.001
Cardiac arrhythmias	1.08 (1.04-1.12)	< 0.001
Diabetes	1.06 (1.03-1.10)	< 0.001

CHD: Coronary heart disease.