Incidence and trends of cardiovascular mortality after common cancers in young adults: Analysis of surveillance, epidemiology and end-results program

Table 1 Characteristics of patients by cancer type

	Breast	Colorectal	Liver	Lung	Ovary	Pancreas	Prostate	All
Age (yr)	42.6 ± 5.3	42.2 ± 6.2	43.4 ± 6.1	44.0 ± 5.1	40.5 ± 7.5	43.5 ± 5.4	46.4 ± 2.8	43.0 ± 5.6
Sex
Female	99.6%	48.3%	22.2%	46.0%	100.0%	42.3%	0.0%	75.6%
Male	0.4%	51.7%	77.8%	54.0%	0.0%	57.7%	100.0%	24.4%
Race
White	75.8%	72.7%	61.0%	73.8%	77.9%	74.5%	68.4%	74.3%
Black	12.9%	16.3%	14.9%	18.4%	9.4%	16.6%	25.9%	15.0%
Other	10.5%	10.0%	23.6%	7.5%	12.0%	8.5%	2.9%	9.9%
Unknown	0.8%	0.9%	0.5%	0.3%	0.7%	0.4%	2.8%	0.9%
Year of diagnosis
1990-1994	9.8%	8.9%	7.9%	13.1%	12.1%	9.1%	3.6%	9.7%
1995-1999	12.7%	11.4%	13.5%	13.9%	13.6%	12.4%	9.2%	12.5%
2000-2004	28.8%	28.8%	31.4%	31.4%	29.0%	28.7%	29.6%	29.3%
2005-2012	48.8%	50.8%	47.3%	41.6%	45.4%	49.7%	57.6%	48.5%
Surgery
No	3.8%	7.8%	63.5%	63.1%	5.4%	61.8%	23.4%	17.0%
Yes	94.2%	89.7%	23.5%	26.9%	92.1%	28.2%	68.2%	78.8%
Unknown	2.1%	2.4%	13.0%	10.0%	2.5%	9.9%	8.4%	4.2%
Stage
Local	53.3%	29.2%	33.9%	11.6%	35.6%	8.8%	90.7%	45.3%
Regional	38.7%	37.2%	27.2%	22.8%	8.5%	26.3%	0.0%	31.2%
Distant	6.1%	29.1%	21.5%	58.7%	50.6%	57.3%	3.4%	19.5%
Unstaged	2.0%	4.5%	17.3%	6.9%	5.3%	7.7%	5.9%	4.0%
Radiation
None	47.8%	94.0%	91.0%	46.7%	97.1%	76.1%	79.3%	59.7%
Beam	47.0%	4.1%	4.6%	48.9%	1.6%	20.3%	10.5%	35.4%
Other	0.7%	0.1%	1.0%	0.4%	0.2%	0.2%	8.0%	1.1%
Unknown	4.4%	1.9%	3.4%	4.0%	1.1%	3.4%	2.3%	3.7%

Table 2 Multivariable model for cardiovascular mortality

	HR	2.5th-ile	97.5th-ile	P-value
Cancer type
Breast vs prostate	1.026	0.837	1.258	0.806
Colorectal vs prostate	1.456	1.196	1.773	< 0.001
Liver vs prostate	3.221	2.495	4.158	< 0.001
Lung vs prostate	3.348	2.797	4.007	< 0.001
Ovarian vs prostate	1.298	0.973	1.731	0.076
Pancreas vs prostate	2.248	1.675	3.016	< 0.001
Demographics
Age at diagnosis (per year)	1.078	1.068	1.089	< 0.001
Black vs white	2.397	2.18	2.635	< 0.001
Other vs white	0.79	0.662	0.942	0.009
Unknown vs white	0.428	0.203	0.903	0.026
Female vs male	0.678	0.595	0.773	< 0.001
Year of diagnosis (per year)	0.97	0.962	0.978	< 0.001
Radiation
Beam radiation vs no radiation	0.814	0.737	0.9	< 0.001
Other radiation vs no radiation	0.463	0.304	0.703	< 0.001
Unknown vs no radiation	0.867	0.673	1.119	0.273
Surgery
Surgery vs no surgery	0.424	0.368	0.489	< 0.001
Unknown vs no surgery	0.937	0.78	1.127	0.491
Stage
Regional vs local	1.394	1.254	1.548	< 0.001
Distant vs local	1.705	1.472	1.976	< 0.001
Unstaged vs local	1.304	1.093	1.555	0.003