Copyright
©The Author(s) 2015.
World J Cardiol. Jul 26, 2015; 7(7): 383-391
Published online Jul 26, 2015. doi: 10.4330/wjc.v7.i7.383
Published online Jul 26, 2015. doi: 10.4330/wjc.v7.i7.383
Table 1 Risk and benefits of non-opioid analgesics
| Substance | Plateletinhibition | Aspirin interaction | Benefits | Risks |
| Aspirin | Irreversible | - | Analgesic, antipyretic, anti-inflammatory | Bleeding events |
| Reduction of cardiovascular events and death | ||||
| Ibuprofen | Reversible (half-life 1-4 h) | Yes | Analgesic, antipyretic, anti-inflammatory | Death |
| Cardiovascular events | ||||
| Bleeding events | ||||
| Naproxen | Reversible (half-life 12-24 h) | Yes | Analgesic, antipyretic, anti-inflammatory | Bleeding events |
| Reduction of cardiovascular events (?) | ||||
| Diclofenac | Reversible (half-life 1-2 h) | No | Analgesic, antipyretic, anti-inflammatory | Death |
| Cardiovascular events | ||||
| Bleeding events | ||||
| Celecoxib | Reversible (half-life 8-13 h) | Yes | Analgesic, antipyretic, anti-inflammatory | Death |
| Less gastrointestinal events | Cardiovascular events | |||
| Paracetamol | Reversible (half-life 1-4 h) | No | Analgesic, antipyretic | Cardiovascular events |
| Less gastrointestinal events | ||||
| Dipyrone | Reversible (half-life 2-4 h) | Yes | Analgesic, antipyretic, anti-inflammatory | Risk of death and cardiovascular events not investigated |
| Less gastrointestinal events |
- Citation: Polzin A, Hohlfeld T, Kelm M, Zeus T. Impairment of aspirin antiplatelet effects by non-opioid analgesic medication. World J Cardiol 2015; 7(7): 383-391
- URL: https://www.wjgnet.com/1949-8462/full/v7/i7/383.htm
- DOI: https://dx.doi.org/10.4330/wjc.v7.i7.383