Angiotensin II-related hypertension and eye diseases

Table 1 Presence of renin-angiotensin system components in the eye

RAS molecule	Eye part	Species	Ref.
Prorenin	Retina	Human	Sramek et al[207], 1988
	Ciliary body	Human	Danser et al[33], 1989
	Vitreous body	Human	Danser et al[33], 1989
Retina	Retina	Human, rabbit	Danser et al[33], 1989
	Ciliary body	Rabbit	Wagner et al[19], 1996
	Choroid	Human, Rabbit	Ramirez et al[208], 1996
	Iris	Rabbit	Ramirez et al[208], 1996
	Vitreous	Human, rabbit	Ramirez et al[208], 1996
	Aqueous humor	Rabbit	Ramirez et al[208], 1996
Angiotensinogen	Retina	Human, rabbit	Sramek et al[209], 1992
	Ciliary body	Human, rabbit	Ramirez et al[208], 1996
	Choroid	Human, rabbit	Wagner et al[19], 1996
	Iris	Human, rabbit	Wagner et al[19], 1996
	Vitreous	Human, rabbit	Wagner et al[19], 1996
	Aqueous humor	Rabbit
ACE1	Retina	Dog, monkey, human	Vita et al[210], 1981
		Rabbit, porcine	Weinreb et al[211], 1985
	Ciliary body	Human, rabbit, porcine	Immonen et al[212], 1987
	Choroid	Dog, monkey, human	Ramirez et al[208], 1996
		Rabbit, porcine	Wagner et al[19], 1996
	Sclera	Dog, monkey	Shiota et al[213], 1997
	Iris	Rabbit, porcine	Geng et al[214], 2003
	Cornea	Human	Savaskan et al[16], 2004
	Vitreous	Dog, monkey, rabbit	Savaskan et al[16], 2004
	Aqueous humor	Human, dog, monkey, rabbit	Savaskan et al[16], 2004
	Tear fluid	Human, rabbit	Savaskan et al[16], 2004
ACE2	Retina	Rodent	Tikellis et al[215], 2004
		Human	Senanayake et al[17], 2007
Chymase	Choroid	Dog	Shiota et al[213], 1997
	Sclera	Dog	Maruichi et al[216], 2004
	Vitreous body	Human
AT1R	Retina	Human	Savaskan et al[16], 2004
	Cornea	Human	Senanayake et al[17], 2007
	RPE	Human	Striker et al[18], 2008
		Rodent	Praddaude et al[104], 2009
AT2R	Retina	Human	Senanayake et al[17], 2007
	RPE	Human	Striker et al[18], 2008
		Rodent	Praddaude et al[104], 2009
Ang I	Retina	Porcine	Danser et al[22], 1994
	Choroid	Porcine
	Vitreous body	Porcine, human
	Aqueous humor	Human
Ang II	Retina	Human, porcine, rabbit	Danser et al[22], 1994
	Ciliary body	Human, rabbit	Ramirez et al[208], 1996
	Choroid	Porcine, human, rabbit	Savaskan et al[16], 2004
	Iris	Rabbit	Senanayake et al[17], 2007
	Cornea	Human
	Vitreous body	Porcine, human, rabbit
	Aqueous humor	Human, rabbit
	RPE	Rodent	Praddaude et al[104], 2009
Ang 1-7	Retina	Human	Senanayake et al[17], 2007

Ang: Angiotensin; RAS: Renin-angiotensin system; AT1R: Angiotensin II type 1 receptor; ACE1: Angiotensin-converting-enzyme 1.