Comprehensive understanding of a rare disease: Cardiac metastatic tumor, a double-center 10-year case review

Table 1 Baseline characteristics of Primary tumors and cardiac metastasis

	All (n = 379)	Primary tumors (n = 153)	Cardiac metastasis (n = 226)	P value
Age (year)	64.0 (55.0, 71.0)	69.0 (61.0, 74.0)	59.5 (50.0, 68)	< 0.001
Male	212 (55.94%)	60 (39.47%)	152 (67.26%)	< 0.001
BMI, kg/m2	23.32 (21.20, 25.66)	23.96 (21.63, 26.59)	22.74 (20.57, 24.88)	< 0.001
Basic vital signs
HR	80.00 (73.00, 88.00)	73.00 (67.00, 81.00)	80.50 (78.00, 96.00)	< 0.001
SBP (mmHg)	122.00 (111.00, 132.00)	122.00 (111.50, 135.50)	120.00 (110.00, 130.00)	0.151
DBP (mmHg)	75.00 (69.00, 82.00)	74.00 (68.00, 81.00)	76.00 (70.00, 82.00)	0.061
Past history
Smoking	155 (40.90)	67 (43.79)	88 (38.94)	0.346
Drinking	102 (26.91)	51 (33.33)	51 (22.57)	0.020
Diabetes	28 (7.71)	15 (10.95)	13 (5.75)	0.072
Hyperlipidemia	25 (6.96)	15 (11.28)	10 (4.42)	0.014
Hypertension	63 (18.98)	17 (16.04)	46 (20.35)	0.350

Data are presented as median (interquartile range) or n (%). BMI: Body mass index; HR: Heart rate; SBP: Systolic blood pressure; DBP: Diastolic blood pressure.

Table 2 Baseline characteristics of pericardial and intracardiac metastasis groups

	All (n = 226)	Pericardial metastasis (n = 161)	Intracardiac metastasis (n = 65)	P value
Age (year)	58.89 ± 12.86	60.01 ± 12.51	56.14 ± 13.40	0.040
Male	152 (67.26)	107 (66.46)	45 (69.23)	0.687
BMI (kg/m2)	22.56 ± 3.00	22.45 ± 2.97	22.96 ± 3.14	0.380
Basic vital signs
RR	20.00 (20.00, 20.00)	20.00 (20.00, 20.00)	20.00 (19.50, 20.00)	0.038
HR	80.50 (78.00, 96.00)	81.00 (78.00, 96.00)	80.00 (78.00, 95.00)	0.683
SBP (mmHg)	120.00 (110.00, 130.00)	120.00 (110.00, 130.00)	120.00 (112.00, 126.00)	0.775
DBP (mmHg)	76.00 (70.00, 82.00)	76.00 (69.00, 81.00)	78.00 (70.00, 85.00)	0.175
Temperature (°C)	36.50 (36.40, 36.60)	36.50 (36.40, 36.60)	36.50 (36.40, 36.60)	0.981
SpO2	99.00 (99.00, 99.00)	99.00 (99.00, 99.00)	99.00 (99.00, 99.00)	0.975
Past history
Smoking	88 (38.94%)	71 (44.10%)	17 (26.15%)	0.010
Drinking	51 (22.57%)	45 (27.95%)	6 (9.23%)	0.001
Diabetes	13 (5.75%)	11 (6.83%)	2 (3.08%)	0.245
Hyperlipidemia	10 (4.42%)	9 (5.59%)	1 (1.54%)	0.140
Hypertension	46 (20.35%)	33 (20.55%)	13 (20.00%)	0.933
Clinical indicators
EF (%)	66.00 (63.00, 69.00)	66.00 (62.00, 69.00)	67.00 (63.00, 71.00)	0.183
D-Dimer (mg/L)	1.06 (0.40, 2.95)	0.84 (0.31, 2.36)	2.16 (1.00, 3.67)	< 0.001
PT (second)	13.30 (12.20, 14.30)	13.00 (12.00, 14.00)	13.90 (12.95, 15.10)	< 0.001
Fibrinogen (g/L)	3.79 (2.65, 4.98)	3.70 (1.83, 4.83)	4.15 (3.23, 5.53)	0.003
INR	1.11 (1.03, 1.35)	1.11 (1.04, 2.20)	1.10 (1.03, 1.22)	0.203
BNP (pg/mL)	137.50 (56.00, 456.00)	120.00 (54.00, 292.00)	324.00 (110.00, 903.00)	0.001
Troponin (ug/L)	1.00 (0.010, 7.75)	0.022 (0.0060, 4.40)	5.35 (2.43, 36.08)	< 0.001
Treatment
Operation	104 (46.02%)	73 (45.34%)	31 (47.69%)	< 0.001

For pericardial metastasis, the main operations are pericardiocentesis drainage and affected pericardium resection. For cardiac metastasis, it is the resection of affected parts. BMI: Body mass index; RR: Respiratory rate; HR: Heart rate; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; SpO₂: Percutaneous arterial oxygen saturation; EF: Ejection fraction; PT: Prothrombin time; INR: International standardized ratio; BNP: Brain natriuretic peptide.

Table 3 Cox proportional hazards model of cardiac metastasis tumor

Variable	Hazard ratio	Standard error	z	P > |z|	95% confidence interval
Metastasis	2.046	0.775	1.89	0.059	0.975	4.297
Age	1.034	0.012	2.89	0.004	1.011	1.057
BNP (pg/mL)	1	0	2.3	0.022	1	1.001
Troponin (ug/L)	1.011	0.004	2.98	0.003	1.004	1.018

BNP: Brain natriuretic peptide.