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Figure 1 Schematic outline of sphingolipid metabolism.
Names of the major intermediates and abbreviations of the enzymes involved are included. SM: Sphingomyelin; SphK: Sphingosine kinase; S1P: Sphingosine-1-phosphate.
Figure 2 Schematic outline of sphingosine-1-phosphate signaling through receptors.
S1P: Sphingosine-1-phosphate; ERK: Extracellular signal-regulated kinases; PKC: Protein kinase C; PLC: Phospholipase C.
- Citation: Kawabori M, Kacimi R, Karliner JS, Yenari MA. Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets. World J Cardiol 2013; 5(4): 75-86
- URL: https://www.wjgnet.com/1949-8462/full/v5/i4/75.htm
- DOI: https://dx.doi.org/10.4330/wjc.v5.i4.75