Li SQ, Min DY, Jiang JW, Li XY, Yang XN, Gu WB, Jiang JH, Chen LH, Nan H, Chen ZY. Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome. World J Cardiol 2024; 16(7): 422-435 [PMID: 39086892 DOI: 10.4330/wjc.v16.i7.422]
Reader's ID:
03893243
Submitted on:
July 25, 2024, 05:54
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Reader Comments:
This paper uses network pharmacology to explore the molecular mechanisms underlying the therapeutic effects of the Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome. However, there are several shortcomings. Firstly, the background is unclear; the chosen prescription is not a common treatment for heart failure, and the rationale for selecting this recipe is not explained. Additionally, the methods section is overly simplistic, lacking detailed descriptions of procedures and experimental conditions. Although the paper predicts multiple potential active ingredients and targets through network pharmacology, it lacks experimental validation, compromising the reliability and applicability of the conclusions. The results section misses further necessary analyses, such as core cluster analysis post-PPI and molecular docking following target identification. The discussion is not detailed, failing to connect the findings to clinical practice or previous research comprehensively. The authors rely on previous studies to support their findings, but the number of citations is insufficient, and the discussion lacks depth. Overall, the study suggests that the selected prescription may act on certain pathways to treat heart failure, but this is insufficient to provide robust clinical evidence. Further experimental validation and detailed analysis are needed to enhance the scientific rigor and practical relevance of the research.
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