Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Biol Chem. May 26, 2014; 5(2): 216-223
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.216
Table 1 Sequences of Cdc4 phospho-degrons in FBW7 substrates
SubstrateCdc4 phospho-degronPhospho-site
CyclinELLTPPQSGT380 S384
MycLPTPPLSPT58 S62
JUNGETPPLSPT239 S243
NOTCH1FLTPSPET2512
TGIFFNTPPPTPT235 T239
SRC3VHSPMASSS505 S509
mTORLLTPSIHLT631
MCL1DGSLPSTPS159 T163 S121
KLF5LNTPDLDM/PPSPPSSE/ NLTPPPSYT244 S303 T324
KLF2PDTPPLSPD/LLTPPSSPT171 S175 T243 S247
SREBPTLTPPPSDAGSPT426 S430 S434
SV40 large T antigenPPTPPPEPT701
MED13/MED13LSSVTLTPPTST326
NF-κB2LPSPPTSDSDSDS707 S711
C/EBPαHPTPPPTPT222 T226
C/EBPσQPTPPQSPT157 S161
HIF1aDQTPSPSDGSTRQSST497 S451
AuroraALSYCHSK/NSSKPSNS245 S387
C-MybLMTPVSEDT572 S556 S528
NRF1LFSPEVES350
PGC1PLTPESPN/GLTPPTTPT263 T295