Copyright
©2014 Baishideng Publishing Group Inc.
World J Biol Chem. May 26, 2014; 5(2): 141-160
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.141
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.141
Nek | Gene/ protein synonyms | Subcellular localization | Established function | Possible additional functions (under investigation) |
1 | NY-REN-55 SRPS2, SRPS2A, KIAA1901 | Cytoplasm, cilia, centrosome, γH2X positive DNA damage sites in nucleus | Stability and function of the primary cilium/polycystic kidney disease[14], DNA damage response to IR and chemical mutagens[2,23-25] | Meiosis[26-28], apoptosis mediated by mitochondria[13] |
2 | NEK2A, NLK1, RP67, HsPK21, SRPS2A | Centrosome | Regulation and promotion of centrosome segregation[33-35] | DNA damage response[127] |
3 | HSPK36, RP11-248G5.5 | Cytoplasm | Regulation of prolactin response[41], microtubule deacetylation in neurons[47] | ? |
4 | STK2, NRK2, pp12301 | Cilia/basal bodies | Microtubule stability (silencing alters sensitivity to vincristine/taxol)[54] | DNA damage response[9], replicative senescence[9], primary cilia function[53] |
5 | - | ? | Skeletal muscle differentiation[60], caspase-3 substrate/ apoptosis[60] | ? |
6 | SID6-1512, RP11-101K10.6 | Citotic spindle, centrosome | Mitotic spindle formation[11-12], centrosome separation[69-70] | DNA damage response[18], NF-kappaB signaling?[3,71] |
7 | - | Spindle poles | Mitotic spindle formation[12,88], centrosome separation[69-70] | DNA damage response?1 |
8 | JCK, NEK12A, NPHP9, RHPD2 | Centrosome, cilia, γH2X positive DNA damage sites in nucleus | Stability and function of the primary cilium/polycystic kidney disease[95], DNA damage response[10] | Integration of primary cilia function and DNA damage response[10] |
9 | NERCC, NERCC1,KIAA1995, (NEK8) | Spindle poles, centrosome, cytoplasm | Mitotic spindle formation[106], centrosome separation[100] | ? |
10 | - | Possible centrosome/pericentriolar localization (?) | DNA damage response after UV induced damage[74] | Centrosome function? |
11 | - | Nucleus, nucleoli | DNA damage response induced by IR[73] | ? |
- Citation: Meirelles GV, Perez AM, de Souza EE, Basei FL, Papa PF, Melo Hanchuk TD, Cardoso VB, Kobarg J. “Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases. World J Biol Chem 2014; 5(2): 141-160
- URL: https://www.wjgnet.com/1949-8454/full/v5/i2/141.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v5.i2.141