Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Biol Chem. May 26, 2014; 5(2): 141-160
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.141
Table 1 Subcellular localization, established and possible additional functions of human and mammalian Neks
NekGene/ protein synonymsSubcellular localizationEstablished functionPossible additional functions (under investigation)
1NY-REN-55 SRPS2, SRPS2A, KIAA1901Cytoplasm, cilia, centrosome, γH2X positive DNA damage sites in nucleusStability and function of the primary cilium/polycystic kidney disease[14], DNA damage response to IR and chemical mutagens[2,23-25]Meiosis[26-28], apoptosis mediated by mitochondria[13]
2NEK2A, NLK1, RP67, HsPK21, SRPS2ACentrosomeRegulation and promotion of centrosome segregation[33-35]DNA damage response[127]
3HSPK36, RP11-248G5.5CytoplasmRegulation of prolactin response[41], microtubule deacetylation in neurons[47]?
4STK2, NRK2, pp12301Cilia/basal bodiesMicrotubule stability (silencing alters sensitivity to vincristine/taxol)[54]DNA damage response[9], replicative senescence[9], primary cilia function[53]
5-?Skeletal muscle differentiation[60], caspase-3 substrate/ apoptosis[60]?
6SID6-1512, RP11-101K10.6Citotic spindle, centrosomeMitotic spindle formation[11-12], centrosome separation[69-70]DNA damage response[18], NF-kappaB signaling?[3,71]
7-Spindle polesMitotic spindle formation[12,88], centrosome separation[69-70]DNA damage response?1
8JCK, NEK12A, NPHP9, RHPD2Centrosome, cilia, γH2X positive DNA damage sites in nucleusStability and function of the primary cilium/polycystic kidney disease[95], DNA damage response[10]Integration of primary cilia function and DNA damage response[10]
9NERCC, NERCC1,KIAA1995, (NEK8)Spindle poles, centrosome, cytoplasmMitotic spindle formation[106], centrosome separation[100]?
10-Possible centrosome/pericentriolar localization (?)DNA damage response after UV induced damage[74]Centrosome function?
11-Nucleus, nucleoliDNA damage response induced by IR[73]?