p53 in stem cells

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Sep 26, 2011 (publication date) through Dec 17, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Sep 26, 2011; 2(9): 202-214
Published online Sep 26, 2011. doi: 10.4331/wjbc.v2.i9.202

Table 1 p53 target genes regulating stem cell behavior

Gene	Regulation	Cell type	Effect	Ref.
nanog	Repression	mESCs	Pro-differentiation	[2]
4-Oct	Repression	mESC	Pro-differentiation	[17]
wnt3, wnt3A, wnt 8a, wnt8b, wnt9A, fzd1, fzd 2, fzd6, fzd8, fzd10, lef1	Activation	mESCs	Anti-differentiation	[31]
miRNA-200c	Activation	Mammary epithelial cells	Inhibition of epithelial-mesenchymal transition	[66]
osterix	Repression	Mesenchymal stem cells	Inhibition of osteogenic differentiation	[80]
runx2	Repression	Mesenchymal stem cells	Inhibition of osteogenic differentiation	[81]
pparγ	Repression	Mesenchymal stem cells	Inhibition of adipogenic differentiation	[82]
duoxa1; duox1	Activation	Neural stem cells	Activation of neurogenesis	[100]
gfi1	Activation	Hematopoietic stem cells	Maintenance of quiescence	[117]
necdin	Activation	Hematopoietic stem cells	Maintenance of quiescence	[117]
p21	Activation	Hematopoietic stem cells	Regulation of HSC amount	[117]

Citation: Solozobova V, Blattner C. p53 in stem cells. World J Biol Chem 2011; 2(9): 202-214
URL: https://www.wjgnet.com/1949-8454/full/v2/i9/202.htm
DOI: https://dx.doi.org/10.4331/wjbc.v2.i9.202