Toll-like receptors are potential therapeutic targets in rheumatoid arthritis

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Jul 26, 2011 (publication date) through Nov 3, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Jul 26, 2011; 2(7): 167-172
Published online Jul 26, 2011. doi: 10.4331/wjbc.v2.i7.167

Table 1 Toll-like receptors, their principal ligands, and the adaptors that serve them

TLRs	Species	Location	Ligands	Adaptors
TLR1/2	Human/mouse	Cell surface	Ac3LP, Glycolipids	MyD88,Tirap
TLR2/6	Human/mouse	Cell surface	Ac2LP, LTA, Zymosan	MyD88,Tirap
TLR3	Human/mouse	Cell compartment	polyI:C, dsRNA	TRIF
TLR4	Human/mouse	Cell surface	LPS, Taxol, Heparan, Hyaluronate, F-prot, RSV, G-prot, VSV, Env prot, MMTV, others	MyD88,Tirap TRIF,TRAM
TLR5	Human/mouse	Cell surface	Flagellin	MyD88
TLR7	Human/mouse	Cell compartment	ssRNA, imiquimod, loxoribine, others	MyD88
TLR8	Human/mouse	Cell compartment	ssRNA, IAQ (R848)	MyD88
TLR9	Human/mouse	Cell compartment	CpG, DNA	MyD88
TLR10	Human	Cell surface	?	?
TLR11	Mouse	Cell surface	Proﬁlin	MyD88
TLR12	Mouse	?	?	?
TLR13	Mouse	?	?	?

TLR: Toll-like receptor.

Citation: Shotorbani SS, Su ZL, Xu HX. Toll-like receptors are potential therapeutic targets in rheumatoid arthritis. World J Biol Chem 2011; 2(7): 167-172
URL: https://www.wjgnet.com/1949-8454/full/v2/i7/167.htm
DOI: https://dx.doi.org/10.4331/wjbc.v2.i7.167