CD47/SIRPα pathways: Functional diversity and molecular mechanisms

Table 1 Major cellular functions performed by CD47/SIRPα signaling

Cell	Physiological function
Erythrocytes	Serves as a marker of self. Maintain membrane integrity and erythrophagocytosis
Macrophages	Regulation of phagocytosis
Dendritic cells	Regulation of phagocytosis. Activation. Mediates immune-inhibitory signals. Transendothelial migration
Neutrophils	Adhesion. Phagocytosis. Transendothelial migration. Inflammatory response. Apoptosis
T-lymphocyte	T-cell survival and differentiation. Activates T-cell receptor-mediated pathways
Monocytes	Transendothelial migration
Endothelial cells	Insulin growth factor signaling
Platelets	Integrins α2β1 and αIIbβ3 expression
Cancer cell	Migration. Invasion. Immune resistance
Natural killer cells	NK cell homeostasis. Graft rejection
Osteoclast cells	Proliferation
Hematopoietic stem cells	Migration

The major functions of CD47/SIRPα signaling on various cells have been shown.