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©The Author(s) 2023.
World J Biol Chem. Oct 17, 2023; 14(5): 84-98
Published online Oct 17, 2023. doi: 10.4331/wjbc.v14.i5.84
Published online Oct 17, 2023. doi: 10.4331/wjbc.v14.i5.84
Table 1 Steady-state kinetic parameters of protein arginine methyltransferase 6 mutants
| PRMT6 mutant | kcat (min-1) | Km (M) | kcat/Km (M-1 min-1) |
| WT | 0.0063 ± 0.0006 | 8.4 ± 0.7 | 0.00075 ± 0.00009 |
| R106K | 0.0122 ± 0.0004 | 9.9 ± 1.2 | 0.0012 ± 0.00015 |
| R174K | N/A | N/A | N/A |
| M60L | 0.0017 ± 0.0002 | 10.0 ± 3.5 | 0.00017 ± 0.00006 |
| M166A | 0.00031 ± 0.00003 | 40 ± 19 | 0.0000077 ± 0.0000037 |
- Citation: Cao MT, Feng Y, Zheng YG. Protein arginine methyltransferase 6 is a novel substrate of protein arginine methyltransferase 1. World J Biol Chem 2023; 14(5): 84-98
- URL: https://www.wjgnet.com/1949-8454/full/v14/i5/84.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v14.i5.84