LIN28A: A multifunctional versatile molecule with future therapeutic potential

Table 1 Classes of mRNA targets[2]

Cell cycle regulation	RNA-binding proteins	Histone components	Glucose metabolism	Early embryogenic genes
Cyclin A	hnRNP F	Histone H2A	IGF receptor	Sox2
CDK4	TDP-43	Histone H4H	Insulin receptor	Sall4
CCNB1	TIA-1	Linker histone H1FX	HMGA2	Oct4

IGF: Insulin-like growth factor 1. Citation: Tsialikas J, Romer-Seibert J. LIN28: roles and regulation in development and beyond. Development 2015; 142: 2397-2404. Copyright© The Authors 2015. Published by The Company of Biologists Ltd.

Table 2 Clinical relevance of LIN28A in certain cancers[25]

Tissue	Primary tumour	Clinical Relevance of LIN28A
Breast	HER2 + tumour	Overexpression correlated with HER2 + tumours
Colon	Primary adenocarcinoma	Expressed in approximately 30% tumours
Kidney	Primary Wilms’ tumour	Overexpressed in late stage
Lung	Small cell lung cancer	Loss increases let-7 levels; inhibits cell cycle
Oesophagus	Primary human tumour	Expression linked to metastasis and poor prognosis
Ovary	Primary ovarian tumour	Knockdown increases let-7 expression

Citation: Thornton JE, Gregory RI. How does Lin28 Let-7 control development and disease? Trends Cell Biol 2012; 22: 474-482. Copyright© The Authors 2012. Published by Elsevier Ltd. All rights reserved.