Effect of Roux-en-Y gastric bypass surgery on intestinal Akkermansia muciniphila

doi:10.4240/wjgs.v8.i4.301

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Apr 27, 2016 (publication date) through Nov 28, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Surg. Apr 27, 2016; 8(4): 301-307
Published online Apr 27, 2016. doi: 10.4240/wjgs.v8.i4.301

Table 1 Fasting blood glucose in different groups before and after surgery (x ± s, mmol/L)

Time point	GK-RYGB	GK-Sham	WS-Sham
1 wk presurgery	6.98 ± 0.32^a	7.07 ± 0.57^a	4.57 ± 0.26
1 wk postsurgery	6.42 ± 0.25^c	6.82 ± 0.49^a	4.25 ± 0.23
2 wk postsurgery	6.01 ± 0.20^a^c^e	6.88 ± 0.52^a	4.37 ± 0.22
3 wk postsurgery	5.60 ± 0.26^a^c^e	6.93 ± 0.52^a	4.37 ± 0.23
4 wk postsurgery	5.72 ± 0.25^a^c^e	7.03 ± 0.52^a	4.50 ± 0.24

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery value. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 2 Serum insulin in different groups before and after surgery (x ± s, pmol/L)

Group	Presurgery		4 wk postsurgery
Group	Fasting	30 min after intragastric glucose	Fasting	30 min after intragastric glucose
GK-RYGB	15.20 ± 0.67^a	27.07 ± 1.07^a	16.05 ± 1.41^a	47.57 ± 4.24^a^c
GK-Sham	15.26 ± 0.76^a	27.49 ± 1.29^a	15.43 ± 0.97^a	27.26 ± 1.26^a
WS-Sham	18.54 ± 0.99	104.00 ± 4.96	19.01 ± 0.42	103.68 ± 4.85

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 3 Homeostasis model assessment-insulin resistance in different groups before and after surgery

Group	Presurgery	4 wk postsurgery
GK-RYGB	4.72 ± 0.34^a	4.07 ± 0.30^c^e
GK-Sham	4.80 ± 0.51^a	4.83 ± 0.54
WS-Sham	3.75 ± 0.07	3.74 ± 0.20

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 4 Serum glucagon-like peptide-1 in different groups before and after surgery (x ± s, pmol/L)

Group	Presurgery	4 wk postsurgery
GK-RYGB	21.01 ± 0.90^a	34.36 ± 1.46^c^e
GK-Sham	21.19 ± 0.53^a	24.98 ± 2.63^a
WS-Sham	29.31 ± 1.51	32.13 ± 1.52

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 5 Amount of Akkermansia muciniphila in different groups before and after surgery (log10 copies/g)

Group	Presurgery	4 wk postsurgery
GK-RYGB	7.85 ± 0.09^a	9.34 ± 0.18^a^c^e
GK-Sham	7.79 ± 0.08^a	7.82 ± 0.09^a
WS-Sham	8.51 ± 0.08	8.82 ± 0.06

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Citation: Yan M, Song MM, Bai RX, Cheng S, Yan WM. Effect of Roux-en-Y gastric bypass surgery on intestinal Akkermansia muciniphila. World J Gastrointest Surg 2016; 8(4): 301-307
URL: https://www.wjgnet.com/1948-9366/full/v8/i4/301.htm
DOI: https://dx.doi.org/10.4240/wjgs.v8.i4.301