Acute appendicitis: Epidemiology, treatment and outcomes- analysis of 16544 consecutive cases

Table 1 Distribution of patients among age categories and sex

Age category	Sex		Total
	F	M	n	Among total
0-1	1	0	1	0.01%
	100.00%	0.00%
1-6	239	369	608	3.68%
	39.30%	60.70%
7-13	1673	2322	3995	24.15%
	41.90%	58.10%
14-17	1314	1119	2433	14.71%
	54.00%	46.00%
18-25	1904	1628	3532	21.35%
	53.90%	46.10%
26-35	1167	1556	2723	16.46%
	42.90%	57.10%
36-45	529	889	1418	8.57%
	37.30%	62.70%
46-55	255	514	769	4.65%
	33.20%	66.80%
56-65	165	352	517	3.13%
	31.90%	68.10%
66-75	135	205	340	2.06%
	39.70%	60.30%
76-85	89	79	168	1.02%
	53.00%	47.00%
> 85	23	17	40	0.24%
	57.50%	42.50%
Total	7494	9050	16544	100.00%
	45.30%	54.70%

Table 2 Surgical technique: Data about surgical techniques were available only after year 2000

	Open appendectomy	Laparoscopic appendectomy	Total	Univariate analysisP value	Multivariate analysis
					OR	P value
n (%)	6321 (52)	5734 (48)	12055
Age	22.79 (17.01)	27.57 (15.19)	25.06 (13.55)	< 0.0001	1.018 (1.018-1.0121)	< 0.0001
Sex	M: 61.5%	M: 50.2%	M: 54.6%	< 0.0001	1.80 (1.66-1.94)	< 0.0001
Charlson's	0.33 (0.97)	0.35 (0.87)	0.34 (0.92)	0.385
Year	0.277 (Pearson Correlation)			< 0.0001	1.15 (1.14-1.16)	< 0.0001
Time to surgery (d)	0.66 (1.35)	0.97 (1.53)	0.81 (1.45)	< 0.0001
Lenght of stay (d)	5.28 (3.00)	4.47 (2.66)	4.89 (2.85)	< 0.0001
Mortality	5 (0.1%)	1 (0.001%)	6 (< 0.0001)	0.13

Data are expressed as mean ± SD or number and proportion. Multivariate analysis was calculated for the correlation with laparoscopic approach.

Table 3 Different treatments

	Total	Treatment		Univariate analysis P value	Multivariate analysis
		Appendectomy	Conservative		OR (95%CI)	P value
n (%)	16544	15661 (94.7)	883 (5.3)
Age	24.51 (16.17)	24.39 (15.98)	26.68 (19.04)	< 0.0001	1.006 (0.999-1.013)	0.095
Sex	M: 54.7%	M: 54.6%	M: 56.1%	0.424
Charlson's	0.32 (0.92)	0.31 (0.90)	0.51 (1.26)	< 0.0001	0.826 (0.703-0.868)	< 0.0001
Year	-0.33 (Pearson Correlation)			< 0.0001	0.973 (0.959-0.986)	< 0.0001
Time to surgery (d)		0.85 (1.46)
Length of stay (d)	5.02 (2.92)	5.08 (2.88)	3.98 (3.46)	< 0.0001
Mortality	7 (< 0.0001%)	6 (< 0.0001%)	1 (0.1%)	0.292
Relapse		1.20%	23.10%	< 0.0001
Time to relapse (mo)	Mean	30 (45)	6.5 (15)	< 0.0001
Time to relapse (mo)	Median	11 (1.17-49)	1 (0.16-6.63)
number of hospitalization	1.03 (0.18)	1.01 (0.13)	1.26 (0.47)	< 0.0001
Cumulative LOS	5.20 (3. 56)	5.19 (3.36)	5.47 (6.05)	0.02

Data are expressed as mean ± SD or number and proportion. Multivariate analysis was calculated for the conservative treatment.