Isotretinoin and ulcerative colitis: A case report and review of the literature

Table 1 Laboratory findings

Test	Result	Normal lab values
WBC	21.300 per mcL	4-9 × 1000 per mcL
NEU	95%	43%-75%
LYM	1%	11%-49%
CRP	5.9 mg/dL	0.0-0.5 mg/dL
RBC	3.17 × 106/UL	3.8-5.3 × 106/UL
Hb	9.6 g/dL	13.5-17.0 g/dL
ESR	47 mm/h	M < 50 y.o: 0-15 mm/h
Htc	28%	40.0%-51.0%
Platelets	316 × 103/uL	120-380 × 103/uL
Alb	1.7 g/dL	3.5-5.5 g/dL
Total protein	4.6 g/dL	6.0-8.0 g/dL

WBC: White blood cells; NEU: Neutrophils; LYM: Lymphocyte; CRP: C-reactive protein; RBC: Red blood cells; ESR: Erythrocyte sedimentation rate.

Table 2 Association between isotretinoin and ulcerative colitis in case control studies

Ref.	Population	UC [RR (95%CI)]
Bernstein et al[2]	Residents of Manitoba Canada	1.16 (0.56-2.20)
Crockett et al[8]	US health claims database	4.36 (1.97-9.66)
Etminan et al[7]	Women using oral contraceptives	1.10 (0.44-2.70)
Alhusayen et al[1]	British Columbia residents	1.31 (0.96-1.80)

UC: Ulcerative colitis.