Correlation and clinical significance of hepcidin and STAT3 in colorectal cancer

Table 1 Expression of hepcidin and signal transducer and activator of transcription 3 in colorectal cancer tissues and their correlation with clinical characteristics

Characteristic	N	Hepcidin			STAT3
		Positive cases	Positive rate (%)	P value	Positive cases	Positive rate (%)	P value
Group
CRC	58	39	67.2	< 0.001	37	63.8	< 0.001
Control	20	4	20.0		5	25.0
T stage
T1 and T2	21	9	42.9	< 0.001	10	47.6	0.001
T3 and T4	37	30	81.1		27	73.0
Differentiation
Well	7	4	57.1	0.0071	3	42.9	0.0011
Medium	42	27	64.3		25	59.5
Low	9	8	88.9		9	100
N
Yes	25	18	72.0	0.312	19	76.0	0.003
No	33	21	63.6		18	54.5
M
Yes	13	9	69.2	0.186	9	69.2	0.867
No	45	30	66.7		28	62.2
Age (year)
< 65	14	10	71.4	0.271	9	64.3	0.673
≥ 65	44	29	66.0		28	63.6
Gender
Male	37	25	67.6	0.566	24	64.9	0.438
Female	21	14	66.7		13	61.9

¹Comparison between the well-differentiated group and the low-differentiated group.

STAT3: Signal transducer and activator of transcription 3; CRC: Colorectal cancer; N: Lymph node metastasis; M: Distant metastasis.

Table 2 Correlation between the expression of hepcidin and signal transducer and activator of transcription 3 in colorectal cancer tissues

Hepcidin	STAT3			P value
	N	Positive	Negative
Positive cases	37	33	4	< 0.01
Negative cases	19	4	15

STAT3: Signal transducer and activator of transcription 3.