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Retrospective Cohort Study
Copyright: ©Author(s) 2026.
World J Gastrointest Surg. Jun 27, 2026; 18(6): 117962
Published online Jun 27, 2026. doi: 10.4240/wjgs.117962
Table 1 Comparison of baseline characteristics between two groups, n (%)
Variables
Total (n = 305)
Control group (n = 184)
Observation group (n = 121)
Statistic
P value
Age, mean ± SD59.10 ± 8.1158.75 ± 7.8259.62 ± 8.54t = -0.920.360
Genderχ2 = 0.410.524
Female92 (30.16)58 (31.52)34 (28.10)
Male213 (69.84)126 (68.48)87 (71.90)
BMI, mean ± SD23.09 ± 2.2122.99 ± 2.1923.25 ± 2.24t = -1.030.305
Hypertensionχ2 = 2.880.090
Without230 (75.41)145 (78.80)85 (70.25)
With75 (24.59)39 (21.20)36 (29.75)
Diabetesχ2 = 1.730.188
Without255 (83.61)158 (85.87)97 (80.17)
With50 (16.39)26 (14.13)24 (19.83)
Tumor diameter, mean ± SD4.54 ± 1.574.56 ± 1.584.51 ± 1.57t = 0.270.789
Surgery duration, mean ± SD161.77 ± 33.23161.76 ± 33.45161.79 ± 33.03t = -0.010.995
Pringle time, mean ± SD17.52 ± 5.3517.71 ± 5.2817.24 ± 5.47t = 0.750.454
Child-Pughχ2 = 3.010.083
A258 (84.59)161 (87.50)97 (80.17)
B47 (15.41)23 (12.50)24 (19.83)
Cirrhosisχ2 = 0.680.409
Without60 (19.67)39 (21.20)21 (17.36)
With245 (80.33)145 (78.80)100 (82.64)
Tumor numberχ2 = 0.150.695
Single265 (86.89)161 (87.50)104 (85.95)
Multiple40 (13.11)23 (12.50)17 (14.05)
ECOGχ2 = 1.550.213
0212 (69.51)123 (66.85)89 (73.55)
193 (30.49)61 (33.15)32 (26.45)
Table 2 Longitudinal changes in six-minute walk test distance between groups, mean ± SD
Groupn6WMT
Admission
One week
One month
Observation group121527.46 ± 45.27410.52 ± 54.71a492.71 ± 53.14a
Control group184531.27 ± 51.74337.85 ± 63.28441.63 ± 61.02
F value-F-group = 108.87, F-time = 576.03, F-interaction = 36.73
P value-P-group < 0.001, P-time < 0.001, P-interaction < 0.001
Table 3 Longitudinal changes in Borg perceived exertion scale between groups, mean ± SD
GroupnBorg
Admission
One week
One month
Observation group1210.58 ± 0.373.12 ± 1.18a0.76 ± 0.52b
Control group1840.60 ± 0.383.43 ± 1.351.13 ± 0.63
F value-F-group = 18.05, F-time = 591.45, F-interaction = 10.29
P value-P-group < 0.001, P-time < 0.001, P-interaction < 0.001
Table 4 Longitudinal changes in serum alanine aminotransferase levels between groups, mean ± SD
GroupnALT (U/L)
Admission
One week
One month
Observation group12145.34 ± 13.62152.56 ± 37.29a65.38 ± 21.47a
Control group18443.27 ± 11.56205.69 ± 55.35113.25 ± 34.51
F value-F-group = 211.15, F-time = 1183.77, F-interaction = 115.64
P value-P-group < 0.001, P-time < 0.001, P-interaction < 0.001
Table 5 Longitudinal changes in serum aspartate aminotransferase levels between groups, mean ± SD
GroupnAST (U/L)
Admission
One week
One month
Observation group12147.52 ± 16.43112.34 ± 31.55a53.71 ± 19.66a
Control group18448.35 ± 18.29144.75 ± 39.2586.53 ± 28.45
F value-F-group = 143.11, F-time = 608.14, F-interaction = 51.38
P value-P-group < 0.001, P-time < 0.001, P-interaction < 0.001
Table 6 Longitudinal changes in serum albumin levels between groups, mean ± SD
GroupnALB (g/L)
Admission
One week
One month
Observation group12139.56 ± 8.9134.27 ± 5.4637.89 ± 6.51a
Control group18438.74 ± 8.5233.39 ± 4.9335.73 ± 6.15
F value-F-group = 7.64, F-time = 44.65, F-interaction = 1.04
P value-P-group = 0.006, P-time < 0.001, P-interaction = 0.356
Table 7 Comparison of quality-of-life scores at admission and one month after surgery, mean ± SD
GroupnSymptom
Physical
Social
Psychological
Total
Admission
One month
Admission
One month
Admission
One month
Admission
One month
Admission
One month
Observation group12119.86 ± 5.1325.85 ± 5.6731.12 ± 6.2735.94 ± 6.7123.67 ± 5.8826.84 ± 6.1729.62 ± 5.8435.85 ± 6.53104.27 ± 11.01124.49 ± 11.90
Control group18420.44 ± 5.2824.93 ± 5.8130.78 ± 6.6332.58 ± 6.3124.08 ± 5.6325.75 ± 6.5829.83 ± 6.0933.14 ± 6.46105.12 ± 11.61116.40 ± 12.63
t value-0.95-1.37-0.46-4.440.61-1.450.30-3.570.64-5.59
P value-0.3430.1720.648< 0.0010.5450.1470.763< 0.0010.523< 0.001
Table 8 Multivariable linear regression analysis of factors associated with 1-month quality-of-life total score
VariablesModel 1
Model 2
Model 3
β (95%CI)
P value
β (95%CI)
P value
β (95%CI)
P value
Group
Control0.00 (reference)-0.00 (reference)-0.00 (reference)-
Observation8.09 (5.25-10.92)< 0.0017.93 (5.11-10.75)< 0.0018.18 (5.35-11.02)< 0.001
Table 9 Comparison of complications, n (%)
Group
n
Incision infection
Ascites
Pulmonary infection
Biliary fistula
Total
Observation group1215 (4.13)5 (4.13)2 (1.65)0 (0.00)12 (9.92)
Control group1848 (4.35)16 (8.70)5 (2.72)6 (3.26)35 (19.02)
χ2 value-----4.64
P value-----0.031


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