Comprehensive oral care protocol reduces oral complications in liver transplant recipients: A retrospective cohort study

Table 1 Baseline data of the patients, n (%)/mean ± SD/median (interquartile rage)

	Routine care group (n = 146)	Comprehensive care group (n = 131)	P value
Male	122 (83.56)	98 (74.81)	0.072
Age (years)	51.29 ± 10.60	52.47 ± 11.00	0.365
Body weight (kg)	67.67 ± 12.83	65.83 ± 13.32	0.245
Height (cm)	168.96 ± 6.29	167.54 ± 6.97	0.076
MELD score	40 (28.5-40)	40 (19-40)	0.670

MELD: Model for End-Stage Liver Disease.

Table 2 Comparison of intraoperative data, mean ± SD/median (interquartile rage)/n (%)

	Routine care group (n = 146)	Comprehensive care group (n = 131)	P value
Surgery duration (hours)	6.36 ± 1.49	6.10 ± 1.22	0.107
Allogeneic blood transfusion (U)	8.5 (5.5-12)	7.5 (4.25-10.75)	0.323
Autologous blood transfusion (mL)	800 (500-1250)	600 (450-1025)	0.386
Plasma transfusion (mL)	1100 (700-1250)	1040 (600-1200)	0.284
Platelets (U)	0 (0-0)	0 (0-0)	0.902
Total infusion (mL)	7950 (6535-9515)	6915 (5860-8445)	0.007
Blood loss (mL)	1500 (1000-2000)	1200 (1000-1500)	0.092
Intraoperative immunosuppressive induction
Glucocorticoid	146 (100)	131 (100)	1.000

Table 3 Comparison of postoperative data, n (%)/median (interquartile rage)

	Routine care group (n = 146)	Comprehensive care group (n = 131)	P value
Postoperative immunosuppressive induction
Basiliximab	145 (99.32)	128 (97.71)	0.539
Immunosuppressive maintenance
Cyclosporine A	4 (2.74)	4 (3.05)	1.000
Glucocorticoid	124 (84.93)	103 (78.63)	0.173
Tacrolimus FK506	139 (95.21)	125 (95.42)	0.993
Mycophenolate mofetil	37 (25.34)	101 (77.10)	< 0.001
Postoperative leukopenia	30 (20.55)	24 (18.32)	0.640
Postoperative mechanical ventilation time (hours)	17 (12-60.5)	16 (13-26.5)	0.634
ICU stay (days)	7.9 (5.6-13.5)	7.0 (4.8-11.5)	0.481
OAG score
Day 1	5 (5-6)	5 (5-6)	0.958
Day 2	6 (5-7)	6 (6-6)	0.202
Day 3	6 (6-7)	6 (6-7)	0.008
Day 4	7 (7-8)	7 (7-7)	0.012
Day 5	8 (8-9); n = 142	7 (7-7); n = 117	< 0.001
Day 6	9 (9-10); n = 121	7 (7-7); n = 98	< 0.001
Day 7	9 (9-10); n = 96	7 (7-7); n = 74	< 0.001
Day 8	9 (9-10); n = 83	7 (7-7); n = 66	< 0.001
Day 9	9 (9-10); n = 65	7 (7-7); n = 58	< 0.001
Day 10	9 (9-10); n = 53	7 (7-7); n = 50	< 0.001
Day 11	9 (9-10); n = 47	7 (7-7); n = 42	< 0.001
Day 12	9 (9-10); n = 40	7 (7-7); n = 35	< 0.001
Oral complications	20 (13.70)	7 (5.34)	0.019
Survival rate at ICU discharge	98.63%	99.23%	1.000

Five items of Oral Assessment Guide were included in this study and therefore the scores ranged from 5 to 15. ICU: Intensive care unit; OAG: Oral Assessment Guide.