Retrospective Study
Copyright ©The Author(s) 2025.
World J Gastrointest Surg. Apr 27, 2025; 17(4): 101295
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.101295
Table 1 The general clinical data of the three groups of patients were compared

Modified pancreatic duct stent drainage group (n = 59)
Nasobiliary drainage group (n = 58)
Standard biliary drainage group (n = 58)
χ2/F value
P value
Gender (male/female)35 (59.32)/24 (40.68)33 (56.90)/25 (43.10)32 (55.17)/26 (44.83)0.2080.901
ASA classification (I/II/III)22 (37.29)/28 (47.46)/9 (15.25)11 (18.97)/36 (62.07)/11 (18.97)16 (27.59)/32 (54.24)/10 (17.24)4.8870.299
The number of gallstones in the bile duct (1/2/3/≥ 4)29 (49.15)/7 (11.86)/5 (8.47)/18 (30.51)28 (48.28)/5 (8.62)/5 (8.62)/20 (34.48)23 (39.66)/6 (10.34)/5 (8.62)/24 (41.38)20.92
Age (year)51.42 ± 15.1452.00 ± 16.0851.84 ± 15.840.0210.979
BMI (kg/m2)23.34 ± 3.8223.29 ± 3.6723.16 ± 3.540.0370.964
History of drinking (yes/no)26 (44.07)/33 (55.93)24 (41.38)/34 (58.62)23 (39.66)/35 (60.34)0.2380.888
Time of onset before surgery (hours)35.51 ± 3.2535.94 ± 3.5836.10 ± 4.330.3890.678
Total hospital stay duration (days)9.12 ± 4.3410.62 ± 5.0611.04 ± 5.132.5360.082
Disease duration (month)21.14 ± 4.2822.04 ± 4.0521.67 ± 3.940.7150.491
Surgical duration (minutes)61.04 ± 8.9160.55 ± 6.4260.07 ± 7.490.2330.792
Diameter of the bile duct (cm)1.34 ± 0.431.31 ± 0.481.38 ± 0.510.3180.728
Stone diameter (cm)0.86 ± 0.350.88 ± 0.360.91 ± 0.430.2540.776
Table 2 Comparison of laboratory indicators among three groups of patients, mean ± SD

Modified pancreatic duct stent drainage group (n = 59)
Nasobiliary drainage group (n = 58)
Standard biliary drainage group (n = 58)
F value
P value
P1 value
P2 value
P3 value
AST (U/L)
24 hours before the surgery58.38 ± 18.4955.71 ± 20.0755.75 ± 20.840.2170.642
24 hours after the surgery29.28 ± 3.4748.64 ± 4.3730.13 ± 3.88449.671< 0.001< 0.001< 0.0010.240
ALT (U/L)
24 hours before the surgery85.36 ± 6.4183.15 ± 6.7484.28 ± 6.690.2210.639
24 hours after the surgery35.44 ± 4.7368.54 ± 5.5836.49 ± 6.33650.159< 0.001< 0.001< 0.0010.294
ALP (U/L)
24 hours before the surgery160.42 ± 35.48159.45 ± 34.82158.47 ± 31.821.1530.284
24 hours after the surgery133.09 ± 33.21153.14 ± 36.58134.54 ± 31.256.3900.0020.0020.0030.837
GGT (U/L)
24 hours before the surgery383.45 ± 106.82364.58 ± 119.42322.84 ± 128.940.4020.527
24 hours after the surgery252.64 ± 44.52294.59 ± 51.60255.52 ± 55.3112.314< 0.001< 0.001< 0.0010.668
TBIL (mol/L)
24 hours before the surgery28.65 ± 6.7728.94 ± 6.8228.59 ± 5.821.6030.207
24 hours after the surgery16.08 ± 3.3824.36 ± 4.1616.18 ± 3.6794.115< 0.001< 0.001< 0.0010.878
DBIL (mol/L)
24 hours before the surgery12.53 ± 3.5613.05 ± 3.8113.34 ± 3.643.1650.077
24 hours after the surgery8.59 ± 2.149.93 ± 2.428.96 ± 2.575.2130.0060.0020.0320.328
CRP (mg/L)
24 hours before the surgery104.58 ± 5.89102.57 ± 6.68101.53 ± 5.462.5160.115
24 hours after the surgery83.65 ± 6.9196.08 ± 7.0484.53 ± 6.3162.572< 0.001< 0.001< 0.0010.311
WBC (× 109/L)
24 hours before the surgery11.28 ± 5.9410.64 ± 4.5810.53 ± 5.080.0890.766
24 hours after the surgery9.51 ± 4.419.46 ± 5.029.48 ± 4.660.0030.9970.9420.9840.959
Hb (g/L)
24 hours before the surgery133.54 ± 20.19134.48 ± 20.25134.82 ± 20.722.1710.143
24 hours after the surgery123.14 ± 19.58124.15 ± 18.24123.31 ± 18.940.0430.9580.7960.8050.992
NEU (%)
24 hours before the surgery0.78 ± 0.140.79 ± 0.130.78 ± 0.150.6270.430
24 hours after the surgery0.73 ± 0.080.76 ± 0.090.74 ± 0.071.3370.2650.1570.1590.999
AMY (IU/L)
24 hours before the surgery281.26 ± 94.15274.59 ± 93.08268.42 ± 99.811.1160.292
24 hours after the surgery121.46 ± 44.28175.83 ± 46.82127.43 ± 41.0826.653< 0.001< 0.001< 0.0010.432
Table 3 Comparison of visual analogue scale scores among the three groups of patients, mean ± SD

Modified pancreatic duct stent drainage group (n = 59)
Nasobiliary drainage group (n = 58)
Standard biliary drainage group (n = 58)
F value
P value
P1 value
P2 value
P3 value
VAS (point)
24 hours before the surgery6.25 ± 2.166.24 ± 2.456.26 ± 2.540.0770.781
24 hours after the surgery4.36 ± 1.185.54 ± 1.244.92 ± 1.6810.416< 0.001< 0.0010.0170.033
Table 4 Comparison of complication occurrence in three groups of patients

Modified pancreatic duct stent drainage group (n = 59)
Nasobiliary drainage group (n = 58)
Standard biliary drainage group (n = 58)
χ2 value
P value
Complications14 (23.73)18 (31.03)21 (36.21)2.1800.336
Pancreatitis1 (1.69)0 (0.00)0 (0.00)
Cholangitis0 (0.00)1 (1.72)0 (0.00)
Hemorrhage0 (0.00)2 (3.45)2 (3.45)
Perforation1 (1.69)0 (0.00)1 (1.72)
Wound infection0 (0.00)0 (0.00)1 (1.72)
Hyperamylasemia12 (20.34)15 (25.86)17 (29.31)
Death0 (0.00)0 (0.00)0 (0.00)