Correlations of three scoring systems with the prognosis of patients with liver cirrhosis complicated with sepsis syndrome

Table 1 Comparison of baseline data

	LC group (n = 201)	LC + SS group (n = 225)	t/χ2	P value
Age (years)	55.08 ± 12.10	54.92 ± 12.29	0.135	0.893
Body temperature (°C)	37.59 ± 1.13	37.60 ± 1.08	0.093	0.926
The pulse (times/minutes)	94.60 ± 16.47	95.67 ± 17.45	0.649	0.517
Respiratory rate (times/minutes)	20.94 ± 4.06	21.08 ± 4.05	0.356	0.722
White blood cells (× 109/L)	10.22 ± 6.52	9.60 ± 7.62	0.897	0.370
Neutrophils (× 109/L)	9.70 ± 6.19	8.46 ± 8.78	1.666	0.096
Eosinophils (%)	0.05 ± 0.04	0.04 ± 0.07	1.782	0.076
Lymphocytes (× 109/L)	0.97 ± 0.72	0.90 ± 0.99	0.826	0.409
Hb (g/L)	96.44 ± 22.96	96.19 ± 27.59	0.101	0.920
PLT (× 109/L)	86.39 ± 58.82	82.08 ± 73.73	0.662	0.509
Gender			1.319	0.251
Male/female	141/60	169/56
Smoking history			1.267	0.260
Yes/no	45/156	61/164
Alcohol consumption history			1.531	0.216
Yes/no	67/134	88/137
Body mass index (kg/m2)	23.36 ± 3.25	23.12 ± 3.18	0.770	0.442
Diabetes	47/154	65/160	1.661	0.198
Hypertension	53/148	68/157	0.775	0.379

Hb: Hemoglobin; PLT: Platelets; LC: Liver cirrhosis; SS: Sepsis syndrome.

Table 2 Univariate analysis of prognosis in liver cirrhosis + sepsis syndrome patients

	Surviving patient (n = 167)	Dead patients (n = 58)	t/χ2	P value
Age (years)	53.58 ± 12.32	58.76 ± 11.46	2.807	0.005
Body temperature (°C)	37.75 ± 1.09	37.19 ± 0.96	3.472	< 0.001
The pulse (times/minute)	93.20 ± 17.13	102.79 ± 16.46	3.710	< 0.001
Respiratory rate (times/minute)	20.29 ± 2.88	23.36 ± 5.77	5.256	< 0.001
White blood cells (× 109/L)	8.55 ± 6.97	12.60 ± 8.62	3.578	< 0.001
Neutrophils (× 109/L)	7.61 ± 8.91	10.89 ± 7.95	2.481	0.014
Eosinophils (%)	0.05 ± 0.07	0.03 ± 0.06	1.942	0.053
Lymphocytes (× 109/L)	0.86 ± 0.93	1.01 ± 1.14	0.996	0.320
Hb (g/L)	96.79 ± 27.74	94.43 ± 27.33	0.560	0.576
PLT (× 109/L)	82.00 ± 77.24	82.07 ± 63.14	0.006	0.995
PCT (ng/L)	11.27 ± 5.40	19.39 ± 31.37	3.223	0.002
CRP (mg/L)	57.55 ± 65.80	75.74 ± 63.35	1.831	0.068
LaC (mmol/L)	2.67 ± 2.42	6.08 ± 4.07	7.632	< 0.001
ALT (U/L)	40.60 ± 100.66	188.87 ± 511.08	3.569	< 0.001
AST (U/L)	75.66 ± 273.75	344.20 ± 898.21	3.442	< 0.001
ALB (g/L)	29.99 ± 5.20	27.55 ± 6.18	2.928	0.004
TBiL (μmol/L)	78.35 ± 93.75	166.86 ± 139.29	5.415	< 0.001
PTA (%)	54.58 ± 18.71	33.35 ± 17.58	7.559	< 0.001
Creatinine (μmol/L)	94.31 ± 71.71	215.54 ± 265.12	5.388	< 0.001
Gender			0.304	0.581
Male/female	127/40	42/16
Liver cancer			1.364	0.243
None/have	129/38	49/9
Hypertension			6.224	0.013
None/have	136/31	38/20
Diabetes			3.777	0.052
None/have	138/29	41/17
Coronary heart disease			9.068	0.003
None/have	159/8	48/10
Chronic renal insufficiency			7.822	0.005
None/have	158/9	48/10
Chronic liver failure			47.640	< 0.001
None/have	116/51	10/48
Acute liver failure			59.900	< 0.001
None/have	151/16	24/34
Acute renal failure			81.780	< 0.001
None/have	138/29	10/48
Respiratory failure			67.210	< 0.001
None/have	160/7	29/29
Acute heart failure			28.090	< 0.001
None/have	161/6	42/16
Septic shock			115.900	< 0.001
None/have	144/23	5/53
Hepatic encephalopathy			47.600	< 0.001
None/have	136/31	19/39
Upper gastrointestinal bleeding			6.939	0.008
None/have	128/39	34/24

Hb: Hemoglobin; PLT: Platelets; PCT: Procalcitonin; CRP: C-reactive protein; LAC: Blood lactate; ALT: Alanine transaminase; AST: Aspartate transaminase; ALB: Plasma albumin; TBiL: Total bilirubin; PTA: Prothrombin activity.

Table 3 Assignment table

Factors	Assign
Age (years)	Use raw data for analysis
Body temperature (°C)	Use raw data for analysis
The pulse (times/minute)	Use raw data for analysis
Respiratory rate (times/minute)	Use raw data for analysis
White blood cells (× 109/L)	Use raw data for analysis
Neutrophils (× 109/L)	Use raw data for analysis
PCT (ng/L)	Use raw data for analysis
LaC (mmol/L)	Use raw data for analysis
ALT (U/L)	Use raw data for analysis
AST (U/L)	Use raw data for analysis
ALB (g/L)	Use raw data for analysis
TBiL (μmol/L)	Use raw data for analysis
PTA (%)	Use raw data for analysis
Creatinine (μmol/L)	Use raw data for analysis
MELD scores	Use raw data for analysis
SOFA scores	Use raw data for analysis
MEWS scores	Use raw data for analysis
Hypertension	None assignment is “0”, have assignment is “1”
Coronary heart disease	None assignment is “0”, have assignment is “1”
Chronic renal insufficiency	None assignment is “0”, have assignment is “1”
Chronic liver failure	None assignment is “0”, have assignment is “1”
Acute liver failure	None assignment is “0”, have assignment is “1”
Acute renal failure	None assignment is “0”, have assignment is “1”
Respiratory failure	None assignment is “0”, have assignment is “1”
Acute heart failure	None assignment is “0”, have assignment is “1”
Septic shock	None assignment is “0”, have assignment is “1”
Hepatic encephalopathy	None assignment is “0”, have assignment is “1”
Upper gastrointestinal bleeding	None assignment is “0”, have assignment is “1”

PCT: Procalcitonin; LaC: Blood lactate; ALT: Alanine transaminase; AST: Aspartate transaminase; ALB: Plasma albumin; TBiL: Total bilirubin; PTA: Prothrombin activity; MELD: End-stage liver disease; SOFA: Sequential organ failure assessment; MEWS: Modified early warning score.

Table 4 Multivariate analysis of prognosis in liver cirrhosis + sepsis syndrome patients

Factors	Β	SE	χ2	P value	OR	95%CI
Age (years)	0.225	0.114	3.942	> 0.05	1.241	1.010-1.562
Body temperature (°C)	0.342	0.263	1.714	> 0.05	1.415	0.842-2.364
The pulse (times/minute)	0.169	0.315	0.281	> 0.05	1.180	0.634-2.094
Respiratory rate (times/minute)	0.442	0.216	4.062	> 0.05	1.612	1.031-2.424
White blood cells (× 109/L)	0.176	0.311	0.342	> 0.05	1.194	0.642-2.191
Neutrophils (× 109/L)	0.323	0.164	4.061	> 0.05	1.394	1.004-1.924
PCT (ng/L)	0.340	0.142	5.584	< 0.05	1.401	1.061-1.867
LaC (mmol/L)	0.226	0.114	3.984	> 0.05	1.264	1.001-1.569
ALT (U/L)	1.642	0.342	3.032	> 0.05	4.061	1.942-8.662
AST (U/L)	0.681	0.406	2.716	> 0.05	1.942	0.884-4.621
ALB (g/L)	1.031	0.384	3.621	> 0.05	2.841	1.334-6.256
TBiL (μmol/L)	0.122	0.064	4.103	> 0.05	1.421	1.224-1.618
PTA (%)	0.143	0.043	6.262	> 0.05	1.246	1.081-2.621
Creatinine (μmol/L)	0.257	0.041	3.627	> 0.05	1.581	1.413-2.782
MELD scores	0.327	0.034	46.121	< 0.001	1.815	1.224-2.493
SOFA scores	-0.218	0.036	34.861	< 0.001	1.712	1.344-2.483
MEWS scores	0.912	0.196	24.312	< 0.001	2.493	1.731-3.562
Hypertension	0.612	0.241	4.311	> 0.05	1.814	1.184-2.886
Coronary heart disease	0.381	0.181	4.371	> 0.05	1.460	1.013-2.262
Chronic renal insufficiency	0.348	0.181	3.861	> 0.05	1.693	1.482-1.983
Chronic liver failure	-0.651	0.191	17.593	< 0.001	1.51	1.340-1.798
Acute liver failure	0.284	0.114	6.412	0.010	1.381	1.068-1.663
Acute renal failure	3.816	0.342	70.161	< 0.001	27.062	12.811-60.347
Respiratory failure	-0.421	0.192	15.010	< 0.001	1.663	1.452-2.958
Acute heart failure	0.263	0.234	10.068	< 0.001	1.061	1.020-1.683
Septic shock	0.623	0.172	35.061	< 0.001	1.527	1.384-1.730
Hepatic encephalopathy	-0.311	0.142	4.621	> 0.05	0.721	0.516-0.972
Upper gastrointestinal bleeding	0.612	0.172	3.284	> 0.05	1.554	1.396-1.768

PCT: Procalcitonin; LaC: Blood lactate; ALT: Alanine transaminase; AST: Aspartate transaminase; ALB: Plasma albumin; TBiL: Total bilirubin; PTA: Prothrombin activity; MELD: End-stage liver disease; SOFA: Sequential organ failure assessment; MEWS: Modified early warning score; OR: Odds ratio.