Lymph node dissection does not affect the survival of patients with tumor node metastasis stages I and II colorectal cancer

doi:10.4240/wjgs.v16.i8.2503

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastrointest Surg. Aug 27, 2024; 16(8): 2503-2510
Published online Aug 27, 2024. doi: 10.4240/wjgs.v16.i8.2503

Table 1 Clinical characteristics of patients with colorectal cancer

Characteristics	n (%)
Age (years)	62.8 ± 12.0
Sex
Male	1713 (60.1)
Female	1137 (39.9)
BMI (kg/m²)	22.7 ± 3.2
Smoking	1110 (38.9)
Drinking	898 (31.5)
Hypertension	745 (26.1)
T2DM	350 (12.3)
Surgical history	688 (24.1)
Tumor location
Colon	1363 (47.8)
Rectum	1487 (52.2)
T stage
1	270 (9.5)
2	596 (20.9)
3	725 (25.4)
4	1259 (44.2)
Tumor size
< 5 cm	1702 (59.7)
≥ 5 cm	1148 (40.3)
Total lymph nodes	14.9 ± 7.8
Overall complications	618 (21.7)
Follow-up (months)	38 (1-114)

T2DM: Type 2 diabetes mellitus; BMI: Body mass index.

Table 2 Cox regression analysis of overall survival of T1 patients with colorectal cancer

Risk factors	Univariate analysis		Multivariate analysis
Risk factors	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)	1.045 (1.017-1.134)	0.010^a	1.075 (1.019-1.134)	< 0.01^a
Sex (male/female)	0.592 (0.185-1.894)	0.377
BMI (kg/m²)	0.814 (0.662-1.001)	0.052
T2DM (yes/no)	2.696 (0.845-8.605)	0.094
Tumor location (colon/rectum)	2.109 (0.734-6.060)	0.166
Surgical history (yes/no)	0.467 (0.104-2.087)	0.319
Smoking (yes/no)	0.920 (0.307-2.759)	0.881
Drinking (yes/no)	1.046 (0.348-3.140)	0.936
Hypertension (yes/no)	0.852 (0.236-3.068)	0.806
Tumor size (≥ 5 cm/< 5 cm)	3.418 (1.134-10.299)	0.029^a	3.635 (1.210-10.917)	0.021^a
Lymph nodes	0.989 (0.906-1.079)	0.807
Overall complications (yes/no)	1.227 (0.381-3.944)	0.732

^aP < 0.05.

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; T2DM: Type 2 diabetes mellitus.

Table 3 Cox regression analysis of overall survival of T2 patients with colorectal cancer

Risk factors	Univariate analysis		Multivariate analysis
Risk factors	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)	1.073 (1.040-1.107)	< 0.01^a	1.064 (1.032-1.098)	< 0.01^a
Sex (male/female)	0.718 (0.374-1.376)	0.318
BMI (kg/m²)	0.947 (0.856-1.047)	0.290
T2DM (yes/no)	2.309 (1.015-5.251)	0.046^a	1.966 (0.862-4.485)	0.108
Tumor location (colon/rectum)	1.058 (0.514-2.178)	0.879
Surgical history (yes/no)	0.805 (0.369-1.757)	0.586
Smoking (yes/no)	1.008 (0.516-1.971)	0.981
Drinking (yes/no)	0.836 (0.383-1.825)	0.653
Hypertension (yes/no)	1.405 (0.708-2.791)	0.331
Tumor size (≥ 5 cm/< 5 cm)	0.892 (0.392-2.027)	0.785
Lymph nodes	0.946 (0.893-1.002)	0.057
Overall complications (yes/no)	2.833 (1.498-5.355)	< 0.01^a	2.297 (1.200-4.397)	0.012^a

^aP < 0.05.

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; T2DM: Type 2 diabetes mellitus.

Table 4 Cox regression analysis of overall survival of T3 patients with colorectal cancer

Risk factors	Univariate analysis		Multivariate analysis
Risk factors	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)	1.051 (1.031-1.070)	< 0.01^a	1.047 (1.027-1.066)	< 0.01^a
Sex (male/female)	0.840 (0.557-1.267)	0.405
BMI (kg/m²)	0.946 (0.890-1.006)	0.079
T2DM (yes/no)	2.040 (1.247-3.337)	< 0.01^a	1.470 (0.891-2.425)	0.132
Tumor location (colon/rectum)	0.909 (0.612-1.351)	0.638
Surgical history (yes/no)	0.598 (0.340-1.021)	0.059
Smoking (yes/no)	1.177 (0.789-1.756)	0.424
Drinking (yes/no)	1.252 (0.830-1.888)	0.284
Hypertension (yes/no)	1.316 (0.849-2.040)	0.220
Tumor size (≥ 5 cm/< 5 cm)	0.969 (0.652-1.440)	0.877
Lymph nodes	0.973 (0.946-1.002)	0.067
Overall complications (yes/no)	1.777 (1.181-2.674)	< 0.01^a	1.487 (0.983-2.250)	0.060

^aP < 0.05.

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; T2DM: Type 2 diabetes mellitus.

Table 5 Cox regression analysis of overall survival of T4 patients with colorectal cancer

Risk factors	Univariate analysis		Multivariate analysis
Risk factors	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)	1.061 (1.044-1.079)	< 0.01^a	1.057 (1.039-1.075)	< 0.01^a
Sex (male/female)	0.848 (0.589-1.219)	0.373
BMI (kg/m²)	0.915 (0.864-0.969)	< 0.01^a	0.941 (0.890-0.995)	0.034^a
T2DM (yes/no)	1.139 (0.674-1.923)	0.627
Tumor location (colon/rectum)	0.845 (0.599-1.192)	0.337
Surgical history (yes/no)	1.187 (0.803-1.756)	0.390
Smoking (yes/no)	1.309 (0.928-1.847)	0.125
Drinking (yes/no)	1.096 (0.764-1.574)	0.618
Hypertension (yes/ no)	1.772 (1.240-2.531)	< 0.01^a
Tumor size (≥ 5 cm/< 5 cm)	0.875 (0.620-1.234)	0.447	0.855 (0.605-1.207)	0.373
Lymph nodes	0.979 (0.955-1.003)	0.084
Overall complications (yes/no)	1.766 (1.220-2.558)	< 0.01^a	1.432 (0.982-2.088)	0.062

^aP < 0.05.

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; T2DM: Type 2 diabetes mellitus.

Citation: He F, Qu SP, Yuan Y, Qian K. Lymph node dissection does not affect the survival of patients with tumor node metastasis stages I and II colorectal cancer. World J Gastrointest Surg 2024; 16(8): 2503-2510
URL: https://www.wjgnet.com/1948-9366/full/v16/i8/2503.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i8.2503