Application of 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in recurrent anastomotic tumors after surgery in digestive tract tumors

Table 1 Characteristics of anastomotic inflammation group and recurrent group in patients with gastric cancer and esophageal cancer after operation

Characteristics	Anastomotic		Z	P value
	Inflammation	Recurrence
Gastric cancer (n)	16	13	-	-
Gender (male/female) (n)	15/1	11/2	-	-
Age (mean ± SD, year)	59.56 ± 10.91	60.62 ± 10.52	-0.439	0.661
Body weight (mean ± SD, kg)	55.44 ± 10.35	59.85 ± 9.10	-1.187	0.235
ΜΤV (mean ± SD, cm3)	7.10 ± 3.95	10.71 ± 4.71	-2.017	0.044
Clinical staging (I, II, III, IV) (n)	3, 5, 8, 0	1, 6, 4, 2	-	-
Esophageal cancer (n)	13	11	-	-
Gender (male/female) (n)	11/2	9/2	-	-
Age (mean ± SD, year)	62.38 ± 10.39	61.64 ± 8.65	-0.174	0.862
Body weight (mean ± SD, kg)	56.00 ± 9.08	60.45 ± 5.91	-1.219	0.223
ΜΤV (mean ± SD, cm3)	6.27 ± 3.44	7.75 ± 3.56	-1.13	0.258
Clinical staging (I, II, III, IV) (n)	1, 4, 7, 1	2, 5, 3, 1	-	-

MTV: Metabolic tumor volume.

Table 2 Parameter analysis of fluorodeoxyglucose uptake in anastomotic inflammation and recurrent lesions

Parameters	Anastomotic inflammation (mean ± SD)	Anastomotic recurrence (mean ± SD)	t	P value	95%CI
Gastric cancer
MRFDG (μmol/min/mL)	0.10 ± 0.03	0.19 ± 0.08	-3.819	0.002	-0.139 to -0.039
DVmax (%)	145.74 ± 47.11	94.71 ± 32.17	3.321	0.003	19.504 to 82.546
LBR-MRFDG	1.60 ± 0.42	2.93 ± 1.05	-4.446	< 0.001	-2.026 to -0.714
LBR-DVmax	2.73 ± 1.19	1.47 ± 0.67	3.627	0.001	0.547 to 1.990
Esophageal cancer
MRFDG (μmol/min/mL)	0.10 ± 0.03	0.19 ± 0.07	-3.742	0.002	-0.137 to -0.037
DVmax (%)	144.46 ± 37.99	96.53 ± 23.60	3.628	0.001	20.532 to 75.335
LBR-MRFDG	1.60 ± 0.45	3.14 ± 1.14	-4.188	0.001	-2.331 to -0.741
LBR-DVmax	2.06 ± 0.70	1.10 ± 0.42	3.963	< 0.001	0.458 to 1.462

MRFDG: Fluorodeoxyglucose metabolic rate; LBR: Lesion/background ratio; DV: Volume distribution; CI: Confidence interval.

Table 3 Dynamic positron emission tomography/computed tomography parameters and diagnostic efficacy of lesion/background ratio

Parameters	Sensitivity (%)	Specificity (%)	Threshold value	Youden index	AUC (95%CI)
Gastric cancer
MRFDG	84.62	81.25	0.11	0.659	0.904 (0.736-0.981)
DVmax	76.92	75	112%	0.519	0.808 (0.619-0.929)
LBR-MRFDG	92.31	81.25	1.83	0.736	0.935 (0.778-0.993)
LBR-DVmax	84.62	75	1.77	0.596	0.837 (0.653-0.947)
Esophageal cancer
MRFDG	81.82	84.62	0.13	0.664	0.881 (0.684-0.976)
DVmax	90.91	76.92	117%	0.678	0.853 (0.650-0.963)
LBR-MRFDG	90.91	76.92	1.86	0.678	0.927 (0.743-0.993)
LBR-DVmax	81.82	84.62	1.38	0.664	0.888 (0.693-0.979)

MRFDG: Fluorodeoxyglucose metabolic rate; LBR: Lesion/background ratio; ROC: Receiver operating characteristic; DV: Volume distribution; AUC: Area under the curve; CI: Confidence interval.