Copyright
©The Author(s) 2024.
World J Gastrointest Surg. Jul 27, 2024; 16(7): 2296-2307
Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2296
Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2296
Table 1 Effects of Yangyin Huowei mixture on body mass, diet quantity, and fecal water content of rats (mean ± SD)
Group | Intervention time | n | Body mass (g) | Water intake (mL) | Food intake (g) | Fecal water content (g/%) |
Blank control | Week 0 | 10 | 418.32 ± 22.36b,c | 47.38 ± 2.59b | 32.36 ± 2.96 | 72.23 ± 5.03b |
Week 2 | 10 | 423.16 ± 20.88b,c | 47.55 ± 3.68b | 30.88 ± 1.79 | 70.75 ± 3.67b | |
Week 4 | 10 | 451.22 ± 21.84b,c | 46.69 ± 3.28b | 29.84 ± 2.55 | 69.71 ± 4.25b | |
Week 6 | 10 | 472.12 ± 22.36b,c | 53.72 ± 2.80b | 28.36 ± 2.51 | 68.23 ± 3.18b | |
Week 8 | 10 | 499.24 ± 22.75b,c | 54.07 ± 4.74b | 32.75 ± 2.79 | 72.62 ± 3.53b | |
Model | Week 0 | 10 | 378.75 ± 18.78a | 62.47 ± 5.79a | 26.84 ± 1.94a | 66.71 ± 5.70a |
Week 2 | 10 | 399.32 ± 18.68a | 60.92 ± 3.76a,c | 28.26 ± 2.37a | 58.13 ± 4.95a,c | |
Week 4 | 10 | 410.27 ± 18.35a | 63.50 ± 6.33a,c | 30.65 ± 2.35a | 60.52 ± 4.69a,c | |
Week 6 | 10 | 418.16 ± 20.07a | 56.47 ± 4.02a,c | 25.78 ± 2.01a | 61.65 ± 3.72a,c | |
Week 8 | 10 | 439.72 ± 17.20a,c | 65.90 ± 4.79a,c | 27.78 ± 2.08a,c | 57.65 ± 5.01a,c | |
Low-dose YYHWM | Week 0 | 11 | 370.24 ± 17.58a | 60.58 ± 4.68a | 27.40 ± 1.44a | 65.27 ± 4.18a |
Week 2 | 11 | 389.76 ± 16.91a | 53.04 ± 5.77b | 30.64 ± 3.26a | 70.51 ± 5.23b | |
Week 4 | 11 | 402.16 ± 19.02a | 52.69 ± 4.70b | 28.78 ± 2.27a | 68.65 ± 5.09b | |
Week 6 | 11 | 424.92 ± 15.33a | 40.69 ± 4.13b | 26.68 ± 2.61a | 66.55 ± 4.93b | |
Week 8 | 11 | 448.38 ± 16.91a | 52.01 ± 4.09b | 26.35 ± 3.38a,c | 66.22 ± 3.52b,c | |
Medium-dose YYHWM | Week 0 | 11 | 368.71 ± 16.86a | 61.83 ± 3.49a | 27.07 ± 2.19a | 66.94 ± 2.75a |
Week 2 | 11 | 379.73 ± 16.58a | 52.69 ± 3.82b | 31.72 ± 2.07a | 71.59 ± 4.21b | |
Week 4 | 11 | 398.18 ± 14.81a | 40.69 ± 4.21b | 31.75 ± 1.71a | 71.62 ± 2.57b | |
Week 6 | 11 | 429.22 ± 16.05a | 52.01 ± 3.58b | 28.91 ± 1.77a | 72.78 ± 2.78b | |
Week 8 | 11 | 458.16 ± 13.04a,c | 42.41 ± 4.28b | 29.02 ± 2.39a | 68.89 ± 5.62b | |
High-dose YYHWM-H | Week 0 | 11 | 370.19 ± 15.67a | 62.63 ± 3.97a | 27.33 ± 2.57a | 67.20 ± 6.22a |
Week 2 | 11 | 397.72 ± 16.15a | 48.80 ± 2.75b | 26.91 ± 3.06a | 71.78 ± 4.22b | |
Week 4 | 11 | 419.24 ± 16.24a | 49.32 ± 3.34b | 29.86 ± 1.75a | 69.73 ± 5.45b | |
Week 6 | 11 | 438.43 ± 22.51a,b,c | 47.09 ± 4.97b | 30.58 ± 3.15a | 70.45 ± 5.77b | |
Week 8 | 11 | 455.82 ± 21.74a,b,c | 48.29 ± 3.58b | 28.81 ± 2.24a | 68.68 ± 4.82b | |
Vitacoenzyme | Week 0 | 11 | 365.41 ± 23.80a | 63.30 ± 2.95a | 26.05 ± 1.86a | 65.92 ± 5.92a |
Week 2 | 11 | 379.43 ± 14.28a | 56.87 ± 3.64b | 28.04 ± 1.68a | 67.91 ± 4.44b | |
Week 4 | 11 | 395.63 ± 22.03a | 43.21 ± 2.97b | 25.67 ± 1.94a | 65.54 ± 3.40b | |
Week 6 | 11 | 422.27 ± 16.99a | 45.10 ± 4.62b | 29.15 ± 2.53a | 69.02 ± 5.31b | |
Week 8 | 11 | 444.35 ± 17.74a,b | 45.27 ± 3.32b | 30.24 ± 3.03a | 70.11 ± 4.27b |
Table 2 Effects of Yangyin Huowei mixture on serum PG and G-17 levels in rats (mean ± SD)
Group | n | PG-I (ng/mL) | PG-II (ng/mL) | PGR | G-17 (pg/mL) |
Blank control | 6 | 82.41 ± 3.53d,e | 23.06 ± 0.96d,e | 3.74 ± 0.17 | 493.09 ± 12.17d,e |
Model | 6 | 38.52 ± 1.71c,e | 11.06 ± 0.70c,e | 3.72 ± 0.29 | 225.52 ± 17.44c,e |
Low-dose YYHWM | 6 | 71.98 ± 4.26c,d,e | 18.44 ± 1.01c,d,e | 3.91 ± 0.28b | 433.82 ± 20.18c,d,e |
Medium-dose YYHWM | 6 | 61.64 ± 3.18c,d,e | 16.94 ± 1.19c,d,e | 3.65 ± 0.30 | 375.25 ± 30.03c,d,e |
High-dose YYHWM | 6 | 50.41 ± 3.53b,c,d | 15.33 ± 1.24b,c,d | 3.30 ± 0.29a | 329.22 ± 29.11b,c,d |
Vitacoenzyme | 6 | 45.52 ± 5.71c,d | 13.06 ± 1.10c,d | 3.51 ± 0.57 | 283.53 ± 22.66c,d |
F value | 115.63 | 99.35 | 2.525 | 111.46 | |
P value | < 0.01 | < 0.01 | 0.051 | < 0.01 |
Table 3 Effects of Yangyin Huowei mixture on serum levels of the inflammatory factors IL-1β, IL-6, and TNF-α in rats (mean ± SD, pg/mL)
Group | n | IL-1β | IL-6 | TNF-α |
Blank control | 6 | 30.15 ± 3.07e,f | 69.05 ± 12.72c,e | 209.24 ± 11.62c,e |
Model | 6 | 80.98 ± 4.47d,f | 110.85 ± 6.68d,f | 313.37 ± 36.77d,f |
Low-dose YYHWM | 6 | 71.89 ± 3.03d,e,f | 100.70 ± 6.76d,b,f | 292.47 ± 12.89d,f |
Medium-dose YYHWM | 6 | 46.08 ± 3.11d,e,f | 81.92 ± 6.14a,e | 245.79 ± 10.29d,e |
High-dose YYHWM | 6 | 61.56 ± 4.02d,e,f | 89.20 ± 8.48d,e | 267.30 ± 9.31c,d,e |
Vitacoenzyme | 6 | 52.17 ± 4.12d,e | 80.72 ± 6.04a,e | 239.54 ± 24.15a,e |
F value | 148.76 | 20.44 | 21.17 | |
P value | < 0.01 | < 0.01 | < 0.01 |
Table 4 Effects of YYHWM on protein expression levels of IL-10, JAK1, and STAT3 in rat gastric tissues (mean ± SD)
Group | IL-10/GADPH | JAK1/GADPH | STAT3/GADPH |
Blank control | 0.47 ± 0.10e | 0.49 ± 0.05e,f | 0.24 ± 0.05e,f |
Model | 1.11 ± 0.09d,f | 0.99 ± 0.07d,f | 1.04 ± 0.14c,d |
Low-dose YYHWM | 0.76 ± 0.11a,e | 0.75 ± 0.07d,e,f | 1.07 ± 0.11d,f |
Medium-dose YYHWM | 0.41 ± 0.12c,e | 0.69 ± 0.07b,d,f | 0.50 ± 0.13e |
High-dose YYHWM | 0.19 ± 0.07a,e,f | 0.51 ± 0.05d | 0.55 ± 0.09a,e |
Vitacoenzyme | 0.71 ± 0.08e | 0.38 ± 0.07d | 0.70 ± 0.04b,d |
F value | 33.39 | 35.70 | 31.08 |
P value | < 0.01 | < 0.01 | < 0.01 |
- Citation: Xie SS, Zhi Y, Shao CM, Zeng BF. Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3 pathway. World J Gastrointest Surg 2024; 16(7): 2296-2307
- URL: https://www.wjgnet.com/1948-9366/full/v16/i7/2296.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v16.i7.2296