Reproducibility study of intravoxel incoherent motion and apparent diffusion coefficient parameters in normal pancreas

Table 1 Parameter settings for different machines

Model	TR (ms)	TE (ms)	FOV (mm)	Matrix	Lamination thickness (mm)	Scanning time (min:s)
A	6700	63	380 × 306	108 × 134	5	8:35
B	1897	75	380 × 297	128 × 98	5	3:36
C	4294	67	380 × 300	128 × 100	5	4:57

Table 2 Intraclass correlation coefficient results of parameter values in different parts of the pancreas between different devices

	Machine A vs machine B		Machine A vs machine C		Machine B vs machine C
	ICC (95%CI)	P value	ICC (95%CI)	P value	ICC (95%CI)	P value
D in PaH	0.274 (-0.731, 0.697)	0.232	0.342 (-0.411, 0.712)	0.145	0.728 (0.358, 0.886)	0.002
D* in PaH	-0.186 (-1.545, 0.482)	0.670	0.27 (-0.611, 0.685)	0.220	0.578 (0.02, 0.822)	0.022
f in PaH	-0.209 (-1.818, 0.491)	0.673	0.173 (-0.386, 0.582)	0.272	0.19 (-0.541, 0.622)	0.274
D in PaB	0.456 (-0.332, 0.776)	0.089	0.683 (-0.026, 0.886)	0.028	0.551 (-0.079, 0.814)	0.037
D* in PaB	-0.521 (-3.056, 0.393)	0.815	-0.023 (-1.636, 0.587)	0.519	-0.256 (-2.207, 0.491)	0.691
f in PaB	0.385 (-0.407, 0.739)	0.124	-0.087 (-1.441, 0.534)	0.580	-0.332 (-2.715, 0.515)	0.748
D in PaT	0.324 (-0.614, 0.718)	0.186	0.286 (-0.557, 0.69)	0.201	0.908 (0.781, 0.961)	< 0.001
D* in PaT	0.569 (-0.204, 0.836)	0.060	-0.289 (-2.251, 0.475)	0.713	-0.062 (-1.02, 0.504)	0.569
f in PaT	0.531 (-0.144, 0.806)	0.047	0.35 (-0.633, 0.735)	0.174	0.486 (-0.275, 0.789)	0.073
SNR	0.081 (-0.206, 0.421)	0.312	0.178 (-0.238, 0.551)	0.205	0.067 (-0.152, 0.364)	0.301
ADC value	0.870 (0.691, 0.946)	< 0.001	0.707 (0.393, 0.871)	< 0.001	0.808 (0.590, 0.917)	< 0.001

ICC: Intraclass correlation coefficient; SNR: Signal-to-noise ratio; PaH: Pancreatic head; ADC: Apparent diffusion coefficient; D: Diffusion coefficient; PaT: Pancreatic tail; PaB: Pancreatic body; f: Perfusion fraction; D*: False diffusion coefficient.

Table 3 Comparison of diffusion coefficient, false diffusion coefficient, and perfusion fraction values of the pancreatic head, body, and tail measured using machines A, B, and C

Region and parameter	Machine A	Machine B	Machine C	Mixed liner model		Post-hoc test		95% limits of agreement
				F	P value	Pair comparison	P1 value
PaH
D	1.08 ± 0.27	1.15 ± 0.22	1.22 ± 0.23	2.893	0.078	A vs B	0.986	-0.56, 0.38
						A vs C	0.140	-0.47, 0.44
						B vs C	0.311	-0.32, 0.27
D*	0.07 ± 0.04	0.05 ± 0.03	0.05 ± 0.02	2.275	0.128	A vs B	0.139	-0.13, 0.03
						A vs C	0.327	-0.11, 0.03
						B vs C	0.531	-0.05, 0.04
f	0.40 ± 0.18	0.33 ± 0.15	0.23 ± 0.07	15.725	0.001	A vs B	0.483	-0.57, 0.16
						A vs C	0.001	-0.52, 0.00
						B vs C	0.030	-0.40, 0.06
PaB
D	1.05 ± 0.24	1.09 ± 0.18	1.21 ± 0.20	10.060	0.001	A vs B	0.999	-0.46, 0.27
						A vs C	0.003	-0.21, 0.33
						B vs C	0.027	-0.27, 0.31
D*	0.06 ± 0.04	0.05 ± 0.04	0.06 ± 0.02	0.228	0.798	A vs B	0.999	-0.12, 0.05
						A vs C	0.999	-0.08, 0.04
						B vs C	0.999	-0.09, 0.05
f	0.30 ± 0.15	0.37 ± 0.20	0.24 ± 0.07	3.174	0.062	A vs B	0.513	-0.36, 0.27
						A vs C	0.420	-0.39, 0.11
						B vs C	0.066	-0.57, 0.10
PaT
D	1.07 ± 0.16	1.12 ± 0.22	1.15 ± 0.18	2.438	0.112	A vs B	0.999	-0.42, 0.28
						A vs C	0.258	-0.34, 0.29
						B vs C	0.601	-0.19, 0.14
D*	0.08 ± 0.04	0.05 ± 0.03	0.07 ± 0.02	9.451	0.001	A vs B	0.002	-0.10, 0.00
						A vs C	0.999	-0.11, 0.04
						B vs C	0.058	-0.06, 0.06
f	0.25 ± 0.08	0.26 ± 0.10	0.25 ± 0.12	0.191	0.827	A vs B	0.999	-0.20, 0.12
						A vs C	0.999	-0.25, 0.13
						B vs C	0.999	-0.27, 0.12

¹The Bonferroni method was used to adjust the P value. The adjusted P value was equal to the original P value multiplied by 3. PaH: Pancreatic head; ADC: Apparent diffusion coefficient; D: Diffusion coefficient; PaT: Pancreatic tail; PaB: Pancreatic body; f: Perfusion fraction; D*: False diffusion coefficient.