Application of radioactive iodine-125 microparticles in hepatocellular carcinoma with portal vein embolus

Table 1 Comparison of general information between two groups of patients

Characteristic	Joint group, n = 52	Control group, n = 44	Statistical value	P value
Male/female	33/19	29/15	χ2 = 0.062	0.803
Age in yr	62.5 ± 12.0	60.1 ± 13.9	t = 0.908	0.366
Maximum diameter of lesion in cm	7.6 ± 3.0	8.0 ± 3.4	t = 0.612	0.542
Child Pugh grading			χ2 = 0.019	0.890
A	30	26
B	22	18
PVTT position			χ2 = 0.055	0.973
Left branch of portal vein	21	17
Right branch of portal vein	19	16
Left and right branches of portal vein	12	11
HBsAg positivity	35	30	χ2 = 0.008	0.927

HBsAg: Hepatitis B surface antigen; PVTT: Portal vein tumor.

Table 2 Comparison of tumor lesion efficacy between two groups of patients

Group	Cases	Curative effect				Remission rate	Total effective rate
		CR	PR	SD	PD
Joint group	52	3	28	19	2	31 (59.62)	50 (96.15)
Control group	44	1	16	23	4	17 (38.64)	40 (90.91)
χ2 value						4.196	1.119
P value						0.041	0.290

Date are n (%). CR: Complete response; PD: Progression; PR: Partial response; SD: Stable.

Table 3 Comparison of portal vein tumors efficacy between two groups of patients

Group	Cases	Therapeutic effect				Relief rate	Total effective rate
		CR	PR	SD	PD
Joint group	52	9	33	9	1	42 (80.77)	51 (98.08)
Control group	44	4	22	15	3	26 (59.09)	41 (93.18)
χ2 value						5.421	1.430
P value						0.020	0.232

Data are n (%). CR: Complete response; PD: Progression; PR: Partial response; SD: Stable.

Table 4 Comparison of portal vein diameter, liver function indicators, alpha-fetoprotein level, and platelet level between the two groups of patients before and after treatment

Time	Cases	AFP in ng/mL	ALT in U/L	AST in U/L	TBIL in μmol/L	PLT as 109/L	Portal vein trunk diameter in mm	WBC as 109/L
Preoperative
Joint group	52	557.9 ± 196.4	57.2 ± 25.8	66.8 ± 29.0	20.9 ± 5.8	162.6 ± 47.2	13.90 ± 2.51	5.16 ± 1.80
Control group	44	570.2 ± 211.6	54.0 ± 19.8	61.2 ± 25.7	22.5 ± 7.5	167.0 ± 51.6	14.10 ± 2.66	5.30 ± 1.95
t value		0.288	0.651	0.964	1.154	0.426	0.369	0.357
P value		0.774	0.515	0.338	0.251	0.671	0.713	0.722
8 wk after surgery
Joint group	52	138.2 ± 69.5	114.2 ± 47.0	123.0 ± 51.0	35.0 ± 9.4	113.0 ± 55.2	11.20 ± 2.14	3.72 ± 1.15
Control group	44	196.4 ± 73.2	82.6 ± 29.3	89.6 ± 33.7	27.1 ± 8.7	139.0 ± 50.1	12.64 ± 2.00	3.90 ± 1.24
t value		3.890	3.720	3.582	4.126	2.330	3.290	0.719
P value		< 0.001	< 0.001	< 0.001	< 0.001	0.022	0.001	0.473

AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelet; TBIL: Total bilirubin; WBC: White blood cells.