Analysis of lymph node metastasis and survival prognosis in early gastric cancer patients: A retrospective study

Table 1 Univariate analysis of lymph node metastasis in 1011 patients with early gastric cancer

Clinicopathological factors	Assignment	Lymph node metastasis (n = 239)	No lymph node metastasis (n = 772)	χ²	P value
Sex
Male	1	131	430	0.06	0.809
Female	0	108	342
Age
≤ 60 yr old	0	131	432	0.10	0.755
> 60 yr old	1	108	340
BMI
≤ 24 kg/m²	1	162	539	0.56	0.511
> 24 kg/m²	0	77	233
Family history of gastric cancer
Yes	1	92	284	0.23	0.633
No	0	147	488
Smoking history
Yes	1	84	266	0.04	0.845
No	0	155	506
Drinking history
Yes	1	67	191	1.04	0.308
No	0	172	581
Tumor size
≤ 2 cm	0	99	478	31.29	< 0.001
> 2 cm	1	140	294
Tumor location
Upper part of the stomach	1	6	84	15.82	< 0.001
Mid-stomach	2	50	143
Lower part of the stomach	3	183	545
Tumor invasion depth
Mucosal lining	0	53	393	61.11	< 0.001
Submucosa	1	186	379
Vasculatogenic cancer thrombus
No	0	102	64	157.26	< 0.001
Yes	1	137	708
Nerve invasion
No	0	21	24	13.83	< 0.001
Yes	1	218	748
Degree of tumor differentiation
Low differentiation	1	125	376	Z = -2.45	0.014
Medium differentiation	2	88	208
High differentiation	3	26	188

BMI: Body mass index.

Table 2 Multivariate analysis of lymph node metastasis in 1011 patients with early gastric cancer

Clinicopathological factors	Regression coefficients	SE	Wald	OR	95%CI	P value
Tumor diameter	0.59	0.17	12.15	1.80	1.29-2.50	< 0.001
Tumor site	0.40	0.15	7.10	1.49	1.11-1.00	0.008
Depth of tumor invasion	0.97	0.20	24.84	2.65	1.81-3.88	< 0.001
Vasculatogenic cancer thrombus	1.75	0.20	73.99	5.76	3.87-8.59	< 0.001
Degree of tumor differentiation	-0.50	0.12	18.68	0.60	0.48-0.76	< 0.001

OR: Odds ratio.

Table 3 Univariate analysis of prognosis in 1011 patients with early gastric cancer

Clinicopathological factors	Assignment	Cases	3-year overall survival rate (%)	χ²	P value
Sex
Male	1	561	96.6	1.89	0.169
Female	0	450	98.0
Age
≤ 60 yr old	0	563	98.9	5.95	0.015
> 60 yr old	1	448	97.3
BMI
≤ 24 kg/m²	0	701	97.4	0.76	0.384
> 24 kg/m²	1	310	96.9
Family history of gastric cancer
Yes	1	376	96.6	1.69	0.193
No	0	635	99.3
Smoking history
Yes	1	350	97.9	1.42	0.233
No	0	661	98.8
Drinking history
Yes	1	258	98.8	1.09	0.297
No	0	753	98.4
Tumor length
≤ 2 cm	0	577	97.5	0.14	0.708
> 2 cm	1	434	96.9
Tumor location
Upper part of the stomach	1	90	97.4	0.57	0.752
Mid-stomach	2	193	98.1
Lower part of the stomach	3	728	98.2
Tumor invasion depth
Mucosal lining	0	446	98.0	3.39	0.066
Submucosa	1	565	96.6
Vasculatogenic cancer thrombus
No	0	166	97.8	5.26	0.022
Yes	1	845	94.4
Nerve invasion
No	0	45	98.8	0.30	0.587
Yes	1	966	95.1
Degree of tumor differentiation
Low differentiation	1	501	97.7	4.21	0.122
Medium differentiation	2	296	97.6
High differentiation	3	214	95.6
Lymph node metastases
No	0	772	97.9	7.11	0.008
Yes	1	239	95.0

BMI: Body mass index.

Table 4 Multivariate analysis of prognosis in 1011 patients with early gastric cancer

Clinicopathological factors	Regression coefficients	SE	Wald	RR	95%CI	P value
Age > 60 yr	2.25	0.54	17.47	9.5	3.31-27.29	< 0.001
Lymph node metastases	0.79	0.40	3.81	2.2	1.00-4.87	0.049

RR: Risk ratio.