Gastroesophageal signet ring cell carcinoma morbidity and mortality: A retrospective review

Table 1 Patient demographics and comorbidities

Variables	Operative group (N = 63)	Nonoperative group (N = 68)	P value
Demographics
Age	63.3	66.7
Age > 50 yr, n (%)	57 (90.5)	53 (78.0)
Male sex, n (%)	37 (58.7)	42 (61.8)
Ethnicity
European	33	44
Asian	15	4	0.013
Pacific Peoples	6	8
Māori	7	10
MELAA	0	2	0.004
Unknown	2	0
Tumour location
Oesophageal	9	19
Gastro-oesophageal	10	6
Gastric	44	43
Pathological stage
I	18	11
II	10	6
III	30	5
IV	5	46	< 0.001
Current smoker	9	11
Charlson Comorbidity Index	6.5 ± 2.1	7.7 ± 2.5	0.0073

Table 2 Demographic factors and their relationship with survival

Univariate analysis - factors associated with survival
Demographic factors	Hazard ratio	P value
Age	1.003 (0.99-1.02)
Male	0.93 (0.63-1.38)
Smoker	1.12 (0.63-1.98)
European	1.24 (0.84-1.84)
Asian	0.45 (0.24-0.84)	0.013
Pacific Peoples	0.92 (0.50-1.69)
Māori	1.35 (0.78-2.34)
MELAA	11.3 (2.62-48.64)	0.001
Unknown	0.66 (0.16-2.76)
Surgery	0.20 (0.13-0.30)	< 0.001
Stage IV	5.13 (3.35-7.87)	< 0.001
Stage (overall)	2.23 (1.78-2.79)	< 0.001
Charlson Comorbidity Index	1.27 (1.18-1.38)	< 0.001
Proportion of signet ring cells	1.07 (0.72-1.58)
Neoadjuvant chemotherapy	1.87 (0.93-3.76)
Multivariate analysis - factors associated with survival
Stage	1.62 (1.30-2.01)	< 0.001
Surgery	0.27 (0.17-0.42)	< 0.001
Charlson Comorbidity Index	1.19 (1.08-1.30)	< 0.001
Asian ethnicity	0.75 (0.39-1.43)