GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis

Table 1 Positive rates of GLI1 and PTTG1 in colorectal carcinoma tissue samples

Grouping	n	Cancerous tissue	Para-cancerous tissue	χ2	P value
GLI1 positive	103	65 (63.11)	13 (12.62)	55.792	< 0.001
PTTG1 positive	103	58 (56.31)	6 (5.83)	61.292	< 0.001

Table 2 Correlation of GLI1 expression with clinicopathological data of patients undergoing radical surgery for colorectal carcinoma

Grouping	n	GLI1 positive (n = 65), n (%)	GLI1 negative (n = 38), n (%)	χ2	P value
Sex				0.403	0.526
Male	53	35 (53.85)	18 (47.37)
Female	50	30 (46.15)	20 (52.63)
Age				3.504	0.061
< 60 yr old	42	22 (33.85)	20 (53.63)
≥ 60 yr old	61	43 (66.15)	18 (47.37)
Tumor location				0.221	0.638
Colon	43	26 (40.00)	17 (44.74)
Rectum	60	39 (60.00)	21 (55.26)
Differentiation degree				0.552	0.458
High differentiation	23	13 (20.00)	10 (26.32)
Medium–low differentiation	80	52 (80.00)	28 (73.68)
Pathological staging				3.086	0.079
I–II	48	26 (40.00)	22 (57.89)
III–IV	55	39 (60.00)	16 (42.11)
Lymph node metastasis				5.233	0.022
Positive	58	44 (67.69)	17 (44.74)
Negative	45	21 (32.31)	21 (55.26)

Table 3 Association between PTTG1 expression and clinicopathological data of patients undergoing radical surgery for colorectal carcinoma

Grouping	n	PTTG1 positive (n = 58), n (%)	PTTG1 negative (n = 45), n (%)	χ2	P value
Sex				2.728	0.099
Male	53	34 (58.62)	19 (42.22)
Female	50	24 (41.38)	26 (57.78)
Age				3.534	0.060
< 60 yr old	42	19 (32.76)	23 (51.11)
≥ 60 yr old	61	39 (67.24)	22 (48.89)
Tumor location				2.327	0.127
Colon	43	28 (48.28)	15 (33.33)
Rectum	60	30 (51.72)	30 (66.67)
Differentiation degree				0.867	0.352
High differentiation	23	11 (18.97)	12 (26.67)
Low–moderate differentiation	80	47 (81.03)	33 (73.33)
Pathological staging				0.616	0.433
I–II	48	29 (50.00)	19 (42.22)
III–IV	55	29 (50.00)	26 (57.78)
Lymph node metastasis				17.150	< 0.001
Positive	58	43 (74.14)	15 (33.33)
Negative	45	15 (25.86)	30 (66.67)

Table 4 Receiver operating characteristic analysis of the potential of GLI1 and PTTG1 expression to indicate lymph node metastasis in patients undergoing radical surgery for colorectal carcinoma

Grouping	AUC	95%CI	SE	Cut-off	Sensitivity (%)	Specificity (%)
GLI1	0.824	0.739–0.910	0.044	19.76	75.56	84.48
PTTG1	0.811	0.726–0.895	0.043	13.97	68.89	82.76

95%CI: 95% confidence interval.