Risk factors for lymph node metastasis and invasion depth in early gastric cancer: Analysis of 210 cases

Table 1 Baseline characteristics, n (%)

Feature	Value
All cases	210
Age (years), median (years)	(31-91), 65
Sex
Male	156 (74.3)
Female	54 (25.7)
Primary site
Cardia	18 (8.6)
Fundus	2 (1.0)
Body	41 (19.5)
Angle	21 (10.0)
Pylorus	128 (60.9)
Histological differentiation
Well-differentiated adenocarcinoma	14 (6.7)
Moderately differentiated adenocarcinoma	84 (40.0)
Poorly differentiated adenocarcinoma	66 (31.4)
Mucinous adenocarcinoma	3 (1.4)
Signet ring cell carcinoma	41 (19.5)
Papillary adenocarcinoma	1 (0.5)
Lymphoepithelioma-like gastric carcinoma	1 (0.5)
Depth of invasion
Mucosa	93 (44.3)
Submucosa	117 (55.7)
Lymph node metastasis
Metastasis	27 (12.9)
No metastasis	183 (87.1)

Table 2 Univariate and multivariate analysis of risk factors for lymph node metastasis in early gastric cancer, n (%)

Trait	Numerical value	Univariate analysis		Multivariate analysis
		OR (95%CI)	P value	OR (95%CI)	P value
Age, year
≤ 45	7	1.00	-	1.00	-
46-65	102	0.212 (0.043-1.050)	0.057	0.116 (0.011-1.179)	0.069
> 65	101	0.147 (0.029-0.750)	0.021	0.049 (0.004-0.549)	0.014
Sex
Male	156	1.00	-	1.00	-
Female	54	1.533 (0.644-3.653)	0.334	1.359 (0.437-4.219	0.596
Depth of infiltration
Infiltrate into the mucosal layer	93	1.00	-	1.00	-
Infiltrate into the submucosa	117	7.742 (2.252-26.212)	< 0.001	14.346 (2.973-69.234)	< 0.001
Position
Preventriculus	18	1.00	-	1.00	-
Pylorus	2	0.00 (0.00)	0.999	0.00 (0.00)	0.999
Gastric body	41	0.486 (0.114-2.078)	0.330	0.405 (0.076-2.167)	0.291
Gastric angle	21	0.175 (0.018-1.737)	0.137	0.206 (0.017-2.496)	0.214
Sinuses ventriculi	128	0.536 (0.158-1.821)	0.318	0.250 (0.056-1.115)	0.069
Pathological type
Highly differentiated adenocarcinoma	14	1.00	-	1.00	-
Moderately differentiated adenocarcinoma	84	170048308.00 (0.00)	0.999	49334064.34 (0.00)	0.999
Poorly differentiated adenocarcinoma	66	323091785.20 (0.00)	0.999	81279052.88 (0.00)	0.999
Mucinous adenocarcinoma	3	1.00 (0.00)	1.00	0.89 (0.00	1.00
Signet-ring cell carcinoma	41	391626406.30 (0.00)	0.999	122520894.2 (0.00)	0.999
Tumor size, cm
≤ 2	120	1.00	-	1.00	-
> 2	90	2.143 (0.941-4.877)	0.069	2.668 (0.984-7.238)	0.054

OR: Odds ratio.

Table 3 Univariate and multivariate analysis of risk factors for invasion depth in early gastric cancer, n (%)

Trait	Numerical value	Univariate analysis		Multivariate analysis
		OR (95%CI)	P value	OR (95%CI)	P value
Age, year
≤ 45	7	1.00	-	1.00	-
46-65	102	2.222 (0.412-11.987)	0.353	1.867 (0.294-11.835)	0.508
> 65	101	4.926 (0.908-26.725)	0.065	4.812 (0.733-31.586)	0.102
Sex
Male	156	1.00	-	1.00	-
Female	54	0.896 (0.481-1.669)	0.730	1.208 (0.560-2.603	0.630
Position
Preventriculus	18	1.00	-	1.00	-
Pylorus	2	1028029445 (0.00)	0.999	1387506094 (0.00)	0.999
Gastric body	41	0.606 (0.196-1.873)	0.384	0.613 (0.183-2.053)	0.428
Gastric angle	21	0.392 (0.107-1.428)	0.156	0.472 (0.117-1.898)	0.290
Sinuses ventriculi	128	0.930 (0.338-2.557)	0.888	1.227 (0.408-3.688)	0.716
Pathological type
Highly differentiated adenocarcinoma	14	1.00	-	1.00	-
Moderately differentiated adenocarcinoma	84	7.622 (1.605-36.186)	0.011	9.854 (1.865-52.077)	0.007
Poorly differentiated adenocarcinoma	66	13.800 (2.825-67.424)	0.001	19.437 (3.534-106.905)	< 0.001
Mucinous adenocarcinoma	3	9692849057 (0.00)	0.999	2.116E+10 (0.00)	0.999
Signet-ring cell carcinoma	41	4.250 (0.840-21.492)	0.080	8.277 (1.441-46.973)	0.018
Tumor size, cm
≤ 2	120	1.00	-	1.00	-
> 2	90	1.727 (0.988-3.019)	0.055	1.677 (0.883-3.187)	0.114

OR: Odds ratio.