Clinical study of different interventional treatments for primary hepatocellular carcinoma based on propensity-score matching

doi:10.4240/wjgs.v16.i11.3463

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Nov 27, 2024 (publication date) through Nov 4, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Nov 27, 2024; 16(11): 3463-3470
Published online Nov 27, 2024. doi: 10.4240/wjgs.v16.i11.3463

Table 1 Comparison of patients’ baseline data before matching, n (%)

Variable	Group A (n = 125)	Group B (n = 106)	χ²/t	P value
Sex			0.392	0.531
Male	77 (61.60)	61 (57.55)
Female	48 (38.40)	45 (42.45)
Age (years), mean ± SD	54.84 ± 7.95	54.07 ± 9.99	0.656	0.513
Child-Pugh grading			8.331	0.004
Grade A	78 (62.40)	46 (43.40)
Grade B	47 (37.60)	60 (56.60)
TNM stage			7.262	0.007
Stage III	81 (64.80)	50 (47.17)
Stage IV	44 (35.20)	56 (52.83)
ECOG score (score)			9.532	0.002
0-1	83 (66.40)	49 (46.23)
2	42 (33.60)	57 (53.77)

TNM: Tumor-node-metastasis; ECOG: Eastern Cooperative Oncology Group.

Table 2 Comparison of patients’ baseline data after matching, n (%)

Variable	Group A (n = 86)	Group B (n = 86)	χ²/t	P value
Sex			0.214	0.643
Male	51 (59.30)	48 (55.81)
Female	35 (40.70)	38 (44.19)
Age (years), mean ± SD	54.36 ± 8.37	53.84 ± 8.45	0.408	0.684
Child-Pugh grading			8.331	0.004
Grade A	44 (51.12)	44 (51.12)	0.000	1.000
Grade B	42 (48.84)	42 (48.84)
TNM stage			0.023	0.879
Stage III	46 (53.49)	45 (52.33)
Stage IV	40 (46.51)	41 (47.67)
ECOG score (score)			0.024	0.878
0-1	48 (55.81)	49 (56.98)
2	38 (44.19)	37 (43.02)

TNM: Tumor-node-metastasis; ECOG: Eastern Cooperative Oncology Group.

Table 3 Comparison of treatment effect between the two groups, n (%)

Group	CR	PR	SD	PD	ORR	DCR
Group A (n = 86)	34 (39.53)	35 (40.70)	15 (17.44)	2 (2.33)	69 (80.23)	84 (97.67)
Group B (n = 86)	27 (31.40)	25 (29.07)	24 (27.91)	11 (12.79)	52 (60.47)	75 (87.21)
χ²					8.055	6.740
P value					0.005	0.009

CR: Complete response; DCR: Disease control rate; ORR: Objective response rate; PD: Progressive disease; PR: Partial response; SD: Stable disease.

Table 4 Comparison of the total incidence of adverse reactions in groups A and B, n (%)

Group	Nausea and vomiting	Diarrhea	Fever	Leukopenia	Total incidence (%)
Group A (n = 86)	2 (2.33)	1 (1.16)	1 (1.16)	2 (2.33)	6 (6.97)
Group B (n = 86)	5 (5.81)	5 (5.81)	3 (3.49)	6 (6.97)	19 (22.09)
χ²					6.287
P value					0.012

Citation: Cheng XB, Yang L, Lu MQ, Peng YB, Wang L, Zhu SM, Hu ZW, Wang ZL, Yang Q. Clinical study of different interventional treatments for primary hepatocellular carcinoma based on propensity-score matching. World J Gastrointest Surg 2024; 16(11): 3463-3470
URL: https://www.wjgnet.com/1948-9366/full/v16/i11/3463.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i11.3463