Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn’s disease patients

Table 1 Potential surgical and non-surgical risk factors of anastomosis insufficiency after first-time ileocolic resection in Crohn’s disease patients

Surgical risk factors	Non-surgical risk factors
Stapler length	Duration of CD before surgery
Postsurgical complications	Biological treatment before surgery
Obstruction > 3 days	Malnutrition before surgery (BMI < 20)
Anastomotic bleeding
Anastomotic (micro) leakage1

¹Defined as increased inflammatory markers and pathological discharge from the drain or confirmed in computed tomography.

CD: Crohn's disease; BMI: Body mass index.

Table 2 Patient characteristics, n (%)

Characteristics
Age (mean)	18-73 years (35.5)
Sex	37 women, 40 men
CD diagnosed before surgery/postoperatively confirmed CD	69 (89.6)/8 (10.4)
Pharmacological therapy before first-time resection: Biological treatment; non-biological treatment1	18 (23.4); 45 (58.4)

¹Steroids and/or immunosuppressants.

CD: Crohn's disease.

Table 3 Indication for primarily ileocolic resection in Crohn’s disease patients

Indication	n (%)
Stenosis	41 (53.2)
Abscess	29 (37.7)
Fistula	6 (7.8)
Perforation	1 (1.3)

Table 4 Postoperative complications after primarily ileocolic resection in Crohn’s disease patients

Complication	n (%)
Sub-ileus	12 (15.6)
Anastomotic bleeding	10 (13)
Pneumonia/hydrothorax	8 (10.4)
Wound infection	4 (5.2)
Anastomotic leakage (minor or suspected)	3 (3.9)
Intra-peritoneal abscess	2 (2.6)

Table 5 Indication for re-intervention due to anastomotic insufficiency

Indication	n (%)
Stenosis	5 (42)
Inflammatory lesions	4 (33)
Abscess	2 (17)
Fistula	1 (8)