Clinical significance of serum oxidative stress and serum uric acid levels before surgery for hepatitis B-related liver cancer

Table 1 Comparison of clinicopathological features between the recurrence group and non-recurrence group, n (%)

Groups	Recurrence group (n = 69)	Non-recurrence group (n = 41)	t value	P value
Age (mean ± SD, yr)	54.63 ± 15.58	55.10 ± 15.29
Gender			3.497	0.061
Men	40 (57.97)	31 (75.61)
Female	29 (42.03)	10 (24.39)
HbsAg			0.313	0.576
Negative	22 (31.88)	11 (26.83)
Positive	47 (68.12)	30 (73.17)
TNM staging			10.959	0.001
Stage I-II	28 (40.58)	30 (73.17)
Stage III-IV	41 (59.42)	11 (26.83)
Tumor diameter			0.979	0.323
< 5 cm	27 (39.13)	20 (48.78)
≥ 5 cm	42 (60.87)	21 (51.22)
Degree of tumor differentiation			6.353	0.012
Low differentiation	30 (43.48)	28 (68.29)
High differentiation	39 (56.52)	13 (31.71)
Lymph node metastasis			5.208	0.022
Yes	30 (43.48)	9 (21.95)
No	39 (56.52)	32 (78.05)
Number of tumors			0.298	0.585
Multiple	44 (63.77)	24 (58.54)
Single	25 (36.23)	17 (41.46)
Alpha-fetoprotein (μg/L)			3.137	0.077
< 200	37 (53.62)	29 (70.73)
≥ 200	32 (46.38)	12 (29.27)

Table 2 Comparison of preoperative serum oxidative stress level and serum uric acid between the two groups (mean ± SD)

Groups	Oxidative stress			Serum UA (μmol/L)
	SOD (kU/L)	MDA (nmol/L)	GSH (kU/L)
Recurrence group (n = 69)	41.26 ± 7.01	5.78 ± 0.92	29.40 ± 7.92	376.27 ± 82.90
Non-recurrence group (n = 41)	46.82 ± 6.12	4.18 ± 0.82	39.44 ± 8.90	281.36 ± 84.86
t value	4.212	9.176	6.137	5.755
P value	< 0.001	< 0.001	< 0.001	< 0.001

SOD: Superoxide dismutase; MDA: Malondialdehyde; GSH: Glutathione; UA: Uric acid.

Table 3 Multivariate logistic regression analysis of the prognosis of patients with hepatitis B-related liver cancer

Independent variable	B	S. E	Wals	P value	Exp (B)	95%CI
						Lower limit	Upper limit
TNM staging	1.026	0.879	1.361	0.243	2.789	0.498	15.628
Degree of tumor differentiation	1.775	0.914	3.774	0.052	5.899	0.984	35.355
Lymph node metastasis	-1.183	1.005	1.387	0.239	0.306	0.043	2.194
SOD	-0.17	0.084	4.098	0.043	0.844	0.716	0.995
MDA	2.439	0.714	11.676	0.001	11.465	2.83	46.454
GSH	-0.117	0.054	4.74	0.029	0.889	0.8	0.988
Serum UA	0.013	0.005	5.541	0.019	1.013	1.002	1.024

95%CI: 95% confidence interval; SOD: Superoxide dismutase; MDA: Malondialdehyde; GSH: Glutathione; UA: Uric acid.

Table 4 Area under the receiver operating characteristic curve of preoperative serum oxidative stress and serum uric acid levels in predicting prognosis of patients with hepatitis B-related liver cancer

Variable	AUC	Standard error	P value	95%CI
				Lower limit	Upper limit
SOD	0.276	0.050	< 0.001	0.179	0.373
MDA	0.910	0.027	< 0.001	0.858	0.963
GSH	0.199	0.045	< 0.001	0.110	0.288
Serum UA	0.784	0.044	< 0.001	0.697	0.871

95%CI: 95% confidence interval; SOD: Superoxide dismutase; MDA: Malondialdehyde; GSH: Glutathione; UA: Uric acid; AUC: Area under the receiver operating characteristic curve.