Prediction model of stress ulcer after laparoscopic surgery for colorectal cancer established by machine learning algorithm

Table 1 Clinical data of the two groups of patients

Variables	Non-SU group (n = 112)	SU group (n = 23)	χ2/t	P value
Sex, n (%)			0.086	0.769
Male	67 (59.82)	13 (56.52)
Female	45 (40.18)	10 (43.48)
Age (yr), n (%)			15.062	< 0.001
< 65	80 (71.43)	6 (26.09)
≥ 65	32 (28.57)	17 (73.91)
Drinking history, n (%)			2.280	0.131
Yes	46 (41.07)	14 (60.87)
No	66 (58.93)	9 (39.13)
Smoking history, n (%)			0.513	0.474
Yes	61 (54.46)	15 (65.23)
No	51 (45.54)	8 (34.78)
Liver and kidney dysfunction, n (%)			2.035	0.088
Yes	21 (18.75)	8 (34.78)
No	91 (81.25)	15 (65.22)
Lymph node metastasis, n (%)			14.316	< 0.001
Yes	33 (29.46)	17 (73.91)
No	79 (70.54)	6 (26.09)
Postoperative albumin decreased, n (%)			0.263	0.608
< 50	28 (25.00)	4 (17.39)
≥ 50	84 (75.00)	19 (82.61)
Serum potassium (mmol/L)	3.71 ± 0.58	3.73 ± 0.61	-0.154	0.878
Hemoglobin (g/L)	121.28 ± 16.39	115.20 ± 18.52	0.115	0.115
Fasting blood glucose (mmol/L)	10.03 ± 4.54	8.15 ± 3.62	1.866	0.064
CRP (mg/L)	72.37 ± 12.09	75.32 ± 13.47	1.045	0.298
TNF-α (pg/mL)	149.00 ± 18.37	151.75 ± 21.41	0.635	0.526
IL-6 (pg/mL)	14.46 ± 2.28	15.02 ± 3.27	0.990	0.324
IL-8 (pg/mL)	18.43 ± 3.45	19.82 ± 3.04	1.793	0.075
HSP70	2.32 ± 0.56	3.37 ± 0.81	-5.876	< 0.001
HSP90	119.42 ± 17.81	159.35 ± 27.37	-6.712	< 0.001
GAS	121.92 ± 29.39	146.82 ± 35.36	-3.571	< 0.001

CRP: C-reactive protein; TNF-α: Tumor necrosis factor α; IL-6: Interleukin 6; IL-8: Interleukin 8; HSP70: Heat shock protein 70; HSP90: Heat shock protein 90; GAS: Gastrin; SU: Stress ulcer.

Table 2 Multivariate logistic regression analysis of factors affecting postoperative stress ulcer in patients with colorectal cancer

Variables	β	SE	Wald	P value	OR	95%CI
Age	3.301	1.505	4.811	0.028	27.146	1.421-518.593
Lymph node metastasis	3.462	1.721	4.048	0.044	31.869	1.093-928.858
HSP70	2.496	1.132	4.857	0.028	12.129	1.318-928.858
HSP90	0.169	0.061	7.758	0.005	1.184	1.051-1.333
GAS	0.041	0.018	5.510	0.019	1.042	1.007-1.079

HSP70: Heat shock protein 70; HSP90: Heat shock protein 90; GAS: Gastrin.