Copyright
©The Author(s) 2023.
World J Gastrointest Surg. Aug 27, 2023; 15(8): 1774-1783
Published online Aug 27, 2023. doi: 10.4240/wjgs.v15.i8.1774
Published online Aug 27, 2023. doi: 10.4240/wjgs.v15.i8.1774
Baseline cohort characteristic | Value |
Age at diagnosis, yr | 56.84 (11.2) |
Female, n (%) | 343 (86.4) |
Year of diagnosis, range | 2015 to 2021 |
AMA M2+, n (%) | 296 (74.6) |
AMA M2-, gp210+, n (%) | 98 (24.7) |
AMA M2-, sp100+, n (%) | 99 (24.9) |
Liver biopsy cases, n (pathological stage, using the Scheuer classification) | 5 (I), 23 (II), 3 (I-II), 5 (II-III), 14 (III), 4 (III-IV), 77 (IV) |
PLT as × 109/L | 88 (142, 207) |
PT in s | 12.2 (13.3, 14.9) |
INR | 0.96 (1.06, 1.23) |
ALB in g/L | 29.9 (35.1, 39.9) |
ALT in U/L | 27 (52, 98) |
AST in U/L | 40 (68, 120) |
TBil in mol/L | 15.8 (24.3, 52.3) |
CREA in mmol/L | 50 (58, 68) |
ALP in IU/L | 122 (204, 351) |
GGT in IU/L | 56 (166, 356) |
GLOBE | 0.34 (1.56, 2.65) |
UK-PBC | 0.02 (0.07, 0.26) |
APRI | 0.69 (1.40, 2.54) |
FIB4 | 2.28 (4.36, 6.93) |
ALBI | -2.51 (-2.03, -1.39) |
Mayo | 1.44 (2.33, 3.52) |
Without cirrhosis, baseline time/end of the follow-up, n (%) | 80 (20.2)/50 (12.6) |
Compensated cirrhosis | 43 (10.9%)/56 (14.1%) |
Decompensated cirrhosis | 274 (69.0%)/288 (72.5%) |
Death | 82 |
Liver-related death | 79 |
LT | 4 |
C-statistic at various follow-up time points (95%CI) | ||
Risk prediction model | Baseline | 1 yr of UDCA |
GLOBE | 0.731 (0.681-0.782) | |
UK-PBC | 0.727 (0.678-0.776) | |
APRI | 0.592 (0.536-0.647) | 0.347 (0.296-0.398) |
FIB4 | 0.648 (0.593-0.704) | 0.680 (0.628-0.732) |
ALBI | 0.705 (0.656-0.755) | 0.725 (0.672-0.778) |
Mayo | 0.702 (0.653-0.751) | 0.740 (0.690-0.791) |
Univariate analyses | Multivariable analyses | |||||
Prognostic score | Hazard ratio | 95%CI | P value | Hazard ratio | 95%CI | P value |
GLOBE | 1.703 | 1.474-1.967 | < 0.001 | 1.582 | 1.029-2.433 | 0.037 |
UK-PBC | 6.046 | 3.479-10.510 | < 0.001 | 1.012 | 0.330-3.102 | 0.983 |
APRI | 0.998 | 0.971-1.024 | 0.860 | 0.918 | 0.812-1.038 | 0.171 |
FIB4 | 1.005 | 0.997-1.013 | 0.242 | 1.008 | 0.991-1.024 | 0.369 |
ALBI | 2.546 | 1.955-3.316 | < 0.001 | 1.194 | 0.595-2.40 | 0.618 |
Mayo | 1.495 | 1.348-1.676 | < 0.001 | 1.022 | 0.697-1.497 | 0.913 |
- Citation: Feng J, Xu JM, Fu HY, Xie N, Bao WM, Tang YM. Prognostic scores in primary biliary cholangitis patients with advanced disease. World J Gastrointest Surg 2023; 15(8): 1774-1783
- URL: https://www.wjgnet.com/1948-9366/full/v15/i8/1774.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v15.i8.1774