Observational Study
Copyright ©The Author(s) 2023.
World J Gastrointest Surg. Aug 27, 2023; 15(8): 1774-1783
Published online Aug 27, 2023. doi: 10.4240/wjgs.v15.i8.1774
Table 1 Baseline cohort characteristics
Baseline cohort characteristic
Value
Age at diagnosis, yr56.84 (11.2)
Female, n (%)343 (86.4)
Year of diagnosis, range2015 to 2021
AMA M2+, n (%)296 (74.6)
AMA M2-, gp210+, n (%)98 (24.7)
AMA M2-, sp100+, n (%)99 (24.9)
Liver biopsy cases, n (pathological stage, using the Scheuer classification)5 (I), 23 (II), 3 (I-II), 5 (II-III), 14 (III), 4 (III-IV), 77 (IV)
PLT as × 109/L88 (142, 207)
PT in s12.2 (13.3, 14.9)
INR0.96 (1.06, 1.23)
ALB in g/L29.9 (35.1, 39.9)
ALT in U/L27 (52, 98)
AST in U/L40 (68, 120)
TBil in mol/L15.8 (24.3, 52.3)
CREA in mmol/L50 (58, 68)
ALP in IU/L122 (204, 351)
GGT in IU/L56 (166, 356)
GLOBE0.34 (1.56, 2.65)
UK-PBC0.02 (0.07, 0.26)
APRI0.69 (1.40, 2.54)
FIB42.28 (4.36, 6.93)
ALBI-2.51 (-2.03, -1.39)
Mayo1.44 (2.33, 3.52)
Without cirrhosis, baseline time/end of the follow-up, n (%)80 (20.2)/50 (12.6)
Compensated cirrhosis43 (10.9%)/56 (14.1%)
Decompensated cirrhosis274 (69.0%)/288 (72.5%)
Death82
Liver-related death79
LT4
Table 2 Discriminative performance of the various risk prediction scores calculated at baseline and after 1 year of ursodeoxycholic acid therapy
C-statistic at various follow-up time points (95%CI)
Risk prediction model
Baseline
1 yr of UDCA
GLOBE0.731 (0.681-0.782)
UK-PBC0.727 (0.678-0.776)
APRI0.592 (0.536-0.647)0.347 (0.296-0.398)
FIB40.648 (0.593-0.704)0.680 (0.628-0.732)
ALBI0.705 (0.656-0.755)0.725 (0.672-0.778)
Mayo0.702 (0.653-0.751)0.740 (0.690-0.791)
Table 3 Multivariable analyses of risk prediction scores after 1 year of ursodeoxycholic acid therapy

Univariate analyses
Multivariable analyses
Prognostic score
Hazard ratio
95%CI
P value
Hazard ratio
95%CI
P value
GLOBE1.7031.474-1.967< 0.0011.5821.029-2.4330.037
UK-PBC6.0463.479-10.510< 0.0011.0120.330-3.1020.983
APRI0.9980.971-1.0240.8600.9180.812-1.0380.171
FIB41.0050.997-1.0130.2421.0080.991-1.0240.369
ALBI2.5461.955-3.316< 0.0011.1940.595-2.400.618
Mayo1.4951.348-1.676< 0.0011.0220.697-1.4970.913