Copyright
©The Author(s) 2023.
World J Gastrointest Surg. May 27, 2023; 15(5): 892-905
Published online May 27, 2023. doi: 10.4240/wjgs.v15.i5.892
Published online May 27, 2023. doi: 10.4240/wjgs.v15.i5.892
Variable | Total, n (%) | Training cohort, n (%) | Validation cohort, n (%) | P value |
Total case | 295 | 177 | 118 | |
Follow-up period (mo) | ||||
Median (IQR) | 22.68 (13.54, 37.00) | 23.43 (14.04, 37.00) | 21.00 (12.93, 37.75) | 0.798 |
Age (yr) | ||||
Median (IQR) | 83 (81, 86) | 82 (81, 86) | 83 (81, 86) | 0.738 |
80-89 | 269 (91.19) | 161 (90.96) | 108 (91.53) | 0.867 |
90-99 | 26 (8.81) | 16 (9.04) | 10 (8.47) | |
Sex | ||||
Male | 135 (45.76) | 81 (45.76) | 54 (45.76) | 0.998 |
Female | 160 (54.24) | 96 (54.24) | 64 (54.24) | |
Race | ||||
Chinese | 274 (92.88) | 165 (93.22) | 109 (92.37) | 0.491 |
Malay | 6 (2.03) | 3 (1.69) | 3 (2.54) | |
Indian | 9 (3.06) | 4 (2.26) | 5 (4.24) | |
Others | 6 (2.03) | 5 (2.83) | 1 (0.85) | |
ASA classification | ||||
1 | 2 (0.68) | 1 (0.56) | 1 (0.85) | 0.599 |
2 | 90 (30.51) | 52 (29.38) | 38 (32.20) | |
3 | 187 (63.39) | 112 (63.28) | 75 (63.56) | |
4 | 16 (5.42) | 12 (6.78) | 4 (3.39) | |
BMI (kg/m2) | ||||
Median (IQR) | 22.43 (19.82, 25.68) | 22.51 (20.08, 25.82) | 22.23 (19.31, 25.19) | 0.480 |
≥ 18.5 | 252 (85.42) | 154 (87.01) | 98 (83.05) | 0.346 |
< 18.5 | 43 (14.58) | 23 (12.99) | 20 (16.95) | |
Smoking | ||||
No | 281 (95.25) | 170 (96.05) | 111 (94.07) | 0.434 |
Yes | 14 (4.75) | 7 (3.95) | 7 (5.93) | |
Congestive heart failure within 30 d | ||||
No | 289 (97.97) | 174 (98.31) | 115 (97.46) | 0.686 |
Yes | 6 (2.03) | 3 (1.69) | 3 (2.54) | |
COPD | ||||
No | 291 (98.64) | 174 (98.31) | 117 (99.15) | 0.652 |
Yes | 4 (1.36) | 3 (1.69) | 1 (0.85) | |
Diabetes mellitus | ||||
No | 217 (73.56) | 133 (75.14) | 84 (71.19) | 0.451 |
Yes | 78 (26.44) | 44 (24.86) | 34 (28.81) | |
Preoperative dialysis dependent | ||||
No | 291 (98.64) | 174 (98.31) | 117 (99.15) | 0.652 |
Yes | 4 (1.36) | 3 (1.69) | 1 (0.85) | |
CCI | ||||
0 | 2 (0.68) | 1 (0.56) | 1 (0.85) | 0.118 |
1-2 | 98 (33.22) | 50 (28.25) | 48 (40.68) | |
3-4 | 62 (21.02) | 40 (22.60) | 22 (18.64) | |
≥ 5 | 133 (45.08) | 86 (48.59) | 47 (39.83) | |
Serum albumin (g/dL) | ||||
Median (IQR) | 3.6 (3.2, 3.9) | 3.6 (3.1, 3.9) | 3.6 (3.2, 3.9) | 0.316 |
≥ 3.0 | 261 (88.48) | 160 (90.40) | 101 (85.59) | 0.209 |
2.5-3.0 | 27 (9.15) | 12 (6.78) | 15 (12.71) | |
< 2.5 | 7 (2.37) | 5 (2.82) | 2 (1.70) | |
Priority of operation | ||||
Elective | 206 (69.83) | 121 (68.36) | 85 (72.03) | 0.501 |
Emergency | 89 (30.17) | 56 (31.64) | 33 (27.97) | |
Method of operation | ||||
Open | 135 (45.76) | 80 (45.20) | 55 (46.61) | 0.812 |
Minimally invasive surgery | 160 (54.24) | 97 (54.80) | 63 (53.39) | |
Type of operation | ||||
Right hemicolectomy | 110 (37.29) | 65 (36.72) | 45 (38.14) | 0.942 |
Left hemicolectomy | 8 (2.71) | 5 (2.83) | 3 (2.54) | |
High anterior resection | 86 (29.15) | 51 (28.81) | 35 (29.66) | |
Low anterior resection | 52 (17.63) | 30 (16.95) | 22 (18.64) | |
Subtotal/total colectomy | 13 (4.40) | 10 (5.65) | 3 (2.54) | |
Abdominoperineal resection | 12 (4.07) | 7 (3.95) | 5 (4.24) | |
Hartmann's procedure | 14 (4.75) | 9 (5.09) | 5 (4.24) | |
Stoma | ||||
No | 205 (69.49) | 123 (69.49) | 82 (69.49) | 0.529 |
Loop ileostomy | 23 (7.80) | 10 (5.65) | 13 (11.02) | |
End ileostomy | 6 (2.03) | 5 (2.82) | 1 (0.85) | |
Ileo-colostomy | 8 (2.71) | 5 (2.82) | 3 (2.54) | |
Loop colostomy | 19 (6.44) | 12 (6.78) | 7 (5.93) | |
End colostomy | 34 (11.53) | 22 (12.44) | 12 (10.17) | |
TNM staging | ||||
I | 61 (20.68) | 40 (22.60) | 21 (17.80) | 0.274 |
II | 88 (29.83) | 50 (28.25) | 38 (32.20) | |
III | 129 (43.73) | 80 (45.20) | 49 (41.53) | |
IV | 17 (5.76) | 7 (3.95) | 10 (8.47) | |
Postoperative anastomotic leak | ||||
No | 289 (97.97) | 173 (97.74) | 116 (98.31) | 0.999 |
Yes | 6 (2.03) | 4 (2.26) | 2 (1.69) | |
Postoperative pneumonia | ||||
No | 276 (93.56) | 165 (93.22) | 111 (94.07) | 0.771 |
Yes | 19 (6.44) | 12 (6.78) | 7 (5.93) | |
Postoperative myocardial infarction | ||||
No | 288 (97.63) | 172 (97.18) | 116 (98.31) | 0.706 |
Yes | 7 (2.37) | 5 (2.82) | 2 (1.69) | |
Postoperative 30-d readmission | ||||
No | 255 (86.44) | 154 (87.01) | 101 (85.59) | 0.729 |
Yes | 40 (13.56) | 23 (12.99) | 17 (14.41) | |
Postoperative 30-d mortality | ||||
No | 289 (97.97) | 175 (98.87) | 114 (96.61) | 0.222 |
Yes | 6 (2.03) | 2 (1.13) | 4 (3.39) | |
Postoperative 1-yr mortality | ||||
No | 206 (69.83) | 124 (70.06) | 82 (69.49) | 0.918 |
Yes | 89 (30.17) | 53 (29.94) | 36 (30.51) |
Univariate | Multivariate | |||
HR (95%CI) | P value | HR (95%CI) | P value | |
Age1 | 1.08 (1.02-1.14) | 0.005 | 1.10 (1.04-1.17) | < 0.001 |
Age | ||||
80-89 | Reference | |||
90-99 | 1.31 (0.63-2.73) | 0.470 | - | - |
BMI (kg/m2) | ||||
≥ 18.5 | Reference | Reference | ||
< 18.5 | 1.93 (1.12-3.33) | 0.018 | 1.93 (1.05-3.53) | 0.034 |
Serum albumin (g/dL) | ||||
≥ 3.0 | Reference | Reference | ||
2.5-3.0 | 1.75 (0.90-3.44) | 0.101 | 1.18 (0.55-2.54) | 0.672 |
< 2.5 | 7.15 (2.82-18.2) | < 0.001 | 5.04 (1.82-13.9) | 0.002 |
TNM staging | ||||
I, II, and III | Reference | Reference | ||
IV | 3.95 (2.07-7.55) | < 0.001 | 2.06 (0.95-4.49) | 0.068 |
CCI1 | 1.34 (1.21-1.48) | < 0.001 | 1.41 (1.25-1.59) | < 0.001 |
Priority of operation | ||||
Elective | Reference | Reference | ||
Emergency | 1.81 (1.13-2.88) | 0.013 | 1.35 (0.78-2.33) | 0.278 |
Postoperative pneumonia | ||||
No | Reference | Reference | ||
Yes | 3.46 (1.77-6.78) | < 0.001 | 2.99 (1.43-6.23) | 0.004 |
Postoperative myocardial infarction | ||||
No | Reference | Reference | ||
Yes | 6.01 (2.17-16.6) | < 0.001 | 4.09 (1.37-12.2) | 0.012 |
- Citation: Chok AY, Zhao Y, Chen HLR, Tan IEH, Chew DHW, Zhao Y, Au MKH, Tan EJKW. Elderly patients over 80 years undergoing colorectal cancer resection: Development and validation of a predictive nomogram for survival. World J Gastrointest Surg 2023; 15(5): 892-905
- URL: https://www.wjgnet.com/1948-9366/full/v15/i5/892.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v15.i5.892