Computed tomography perfusion in differentiating portal hypertension: A correlation study with hepatic venous pressure gradient

Table 1 Patients general data

Characteristic	Value
Sex (female/male), n	3/21
Age (yr), mean ± SD	51.3 ± 9.7
Height (cm), mean ± SD	168.7 ± 6.1
Weight (kg), mean ± SD	63.4 ± 12.5
Previous episodes of variceal bleeding, mean ± SD	3 ± 2
Treatment history, n (%)
β blockade only	2 (8.3)
Sclera therapy only	4 (16.7)
β blockade and sclerotherapy	18 (75.0)
Child-Pugh stage, n (%)
A	5 (20.8)
B	18 (75.0)
C	1 (4.2)
Ascites, n (%)
None	16 (66.7)
Mild	2 (8.3)
Severe	6 (25.0)
HVPG in mmHg, n (%)
< 10	11 (45.8)
≥ 10	13 (54.2)

HVPG: Hepatic venous pressure gradient; SD: Standard deviation.

Table 2 Perfusion computed tomography parameters changes before and after transjugular intrahepatic portosystemic shunt

Parameters	Before TIPS	After TIPS	P value
Liver parenchyma
LBF	97.2 ± 32.2	85.8 ± 37.9	0.232
LBV	19.2 ± 5.3	12.1 ± 2.4	< 0.001
HAF (× 10-2)	12.3 ± 6.1	55.3 ± 9.9	< 0.001
Spleen parenchyma
SBF	107.6 ± 32.1	160.6 ± 33.1	< 0.001
SBV	12.1 ± 3.0	18.7 ± 3.4	< 0.001

TIPS: Transjugular intrahepatic portosystemic shunt; LBF: Liver blood flow; LBV: Liver blood volume; HAF: Hepatic arterial fraction; SBF: Spleen blood flow; SBV: Spleen blood volume.

Table 3 Computed tomography perfusion comparisons between clinically significant portal hypertension and non-clinically significant portal hypertension before and after transjugular intrahepatic portosystemic shunt

Parameters	NCSPH (n = 11)	CSPH (n = 13)	P value
Before TIPS
Liver parenchyma
LBF	103.6 ± 23.3	91.7 ± 38.3	0.377
LBV	19.5 ± 2.9	18.9 ± 6.9	0.796
HAF (× 10-2)	5.4 ± 2.8	18.2 ± 10.9	0.001
Spleen parenchyma
SBF	95.9 ± 25.1	117.4 ± 34.9	0.102
SBV	12.4 ± 3.5	12.0 ± 2.7	0.747
After TIPS
Liver parenchyma
LBF	77.5 ± 33.9	92.8 ± 41.0	0.336
LBV	11.3 ± 2.4	12.7 ± 2.2	0.165
HAF (× 10-2)	54.4 ± 11.4	56.0 ± 8.8	0.711
Spleen parenchyma
SBF	150.0 ± 35.7	169.9 ± 29.1	0.153
SBV	19.2 ± 3.8	18.3 ± 3.0	0.522

CSPH: Clinically significant portal hypertension; NCSPH: Non-clinically significant portal hypertension; TIPS: Transjugular intrahepatic portosystemic shunt; LBF: Liver blood flow; LBV: Liver blood volume; HAF: Hepatic arterial fraction; SBF: Spleen blood flow; SBV: Spleen blood volume.