Immunotherapy in combination with chemotherapy for Peutz-Jeghers syndrome with advanced cervical cancer: A case report

Table 1 Overall health parameters during treatments records

Time	April, 2020		September, 2021	January, 2021	November, 2021	December, 2021	January, 2022	February, 2022	March, 2022	April, 2022	May, 2022	June, 2022	July, 2022	August, 2022	September, 2022
Treatment	Admission	Suspend	4 cycles of doxorubicin and carboplatin				9 cycles of sindilizumb in combination with doxorubicin and carboplatin
Temp/°C	37.1	NA	36.2	37	36.5	36.8	36.5	36.3	37.1	36.8	NA	36.8	36.9	37.2	36.9
HR/min	86	NA	76	84	75	79	82	78	82	81	NA	79	75	79	77
RR/min	19	NA	19	18	19	19	19	18	19	17	NA	18	19	18	19
BP/kPa	16.1/7.5	NA	15.4/8.5	18.7/9.7	18.4/11.1	16.9/11.9	16.5/9.3	16.5/9.7	16.0/9.5	14.0/8.4	NA	12.0/8.0	12.5/8.7	13.2/9.6	13.1/8.0
Weight/kg	56	NA	49	51	51.5	52	53.8	52	51.3	50.9	NA	50.5	51	52.3	53
WBC/109/L	5.11	NA	5.4	5.91	5.03	3.6	3.34	2.91	3.23	4.02	NA	4.42	4.51	4.43	4.52
Hb/g/L	133	NA	124	114	105	96	102	102	106	109	NA	111	112	112	113
Alb/g/L	39.9	NA	38.5	42	40.3	36.9	45.6	NA	44.2	43.4	NA	43.1	40.7	37.6	35.3
ALT/U/L	34	NA	20	17	17	16	20	21	22	23	NA	24	36	47	54
AST/U/L	29	NA	25	24	17	8.3	26	NA	27	28	NA	28	37	43	47
CEA/µg/L	1	NA	0.8	1.2	1.1	0.9	1	0.8	0.9	0.8	NA	0.8	0.9	0.8	0.8
CA125/U/mL	11.1	NA	14.4	19.3	14.6	8.9	10.2	10.3	9.7	9.1	NA	9	9.3	9.7	10.7
CA199/U/mL	71.2	NA	146.8	151.5	153.6	154.3	160.8	37.8	32.6	29.8	NA	22.3	24.3	25.6	27.1
CA153/U/mL	4.9	NA	5.6	11.1	9.4	7.3	8.4	9	6.1	5.2	NA	4.6	4.6	4.5	4.5
CA724/U/mL	2.3	NA	2.7	5.7	8.5	14.3	1.5	5.6	3.4	3.8	NA	2.4	2.3	2.2	2.1

HR: Heart rate; RR: Respiratory rate; BP: Blood pressure; WBC: White blood cell; Hb: Haemoglobin; Alb: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CEA: Carcinoma embryonic; CA: Carbohydrate antigen; NA: Not available.

Table 2 Laboratory examinations of the patient after two months of follow-up

Time	Temp/°C	HR/min	RR/min	BP/kPa	Weight/kg	WBC/109/L	Hb/g/L	Alb/g/L	ALT/U/L	AST/U/L	CEA/µg/L	CA125/U/mL	CA199/U/mL	CA153/U/mL	CA724/U/mL
January, 2022	36.5	92	17	14.2/9.6	44.7	5.99	118	43.1	19	17	2.8	32	23	13.6	18.3
November, 2022	37	87	19	14.7/10.4	45.2	6.45	115	35.8	18	23	2.3	31.7	24.6	15.6	19.3

HR: Heart rate; RR: Respiratory rate; BP: Blood pressure; WBC: White blood cell; Hb: Haemoglobin; Alb: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CEA: Carcinoma embryonic; CA: Carbohydrate antigen.