Hepatic venous pressure gradient: Inaccurately estimates portal venous pressure gradient in alcoholic cirrhosis and portal hypertension

Table 1 Baseline characteristics of study patients

	Collateral branch (n = 26)	No collateral branch (n = 108)	P value
Sex (male/female)	24/2 (92.3/7.7%)	95/13 (88.0/12.0%)	0.776
Age (yr)1	52.3 ± 10.7	55.7 ± 10.6	0.143
Indications (n)			0.865
Gastrointestinal bleeding	17	60
Refractory ascites	7	39
Both	1	5
Other conditions	1	4
Child-Puph score1	7.2 ± 1.7	7.3 ± 1.7	0.878
Child-Pugh class			0.644
A	8 (30.8%)	44 (40.7%)
B	15 (57.7%)	53 (49.1%)
C	3 (11.5%)	11 (10.2%)
Hepatocellular carcinoma	3 (11.5%)	12 (11.1%)	> 0.999

¹Data are mean ± SD.

Table 2 Differences between wedged hepatic venous pressure and portal venous pressure and between hepatic venous pressure gradient and portal venous pressure gradient in patients with and without collateral branches

	WHVP (mmHg)	PVP (mmHg)	P value	95%CI	HVPG (mmHg)	PPG (mmHg)	P value	95%CI
With collateral branches (n = 26)	20.89 ± 6.69	34.96 ± 8.08	< 0.001	10.52-17.63	9.86 ± 7.44	25.94 ± 7.42	< 0.001	12.30-19.86
No collateral branch (n = 108)	30.65 ± 8.17	33.25 ± 6.60	0.002	0.99-4.20	18.67 ± 9.05	24.44 ± 6.79	< 0.001	3.91-7.64
Total (n = 134)	28.70 ± 8.78	33.58 ± 6.91	< 0.001	3.18-6.46	16.96 ± 9.41	24.73 ± 6.92	< 0.001	5.98-9.57

95%CI: 95% confidence interval; WHVP: Wedged hepatic venous pressure; PVP: Portal venous pressure; HVPG: Hepatic venous pressure gradient; PPG: Portal venous pressure gradient.

Table 3 Relationships between wedged hepatic venous pressure and portal venous pressure and between hepatic venous pressure gradient and portal venous pressure gradient in patients with and without collateral branches

	WHVP and PVP				HVPG and PPG
	r	R2	P value	95% LoA (mmHg)	r	R2	P value	95% LoA (mmHg)
With collateral branches (n = 26)	0.303	0.092	0.133	-3.16-31.31	0.208	0.043	0.309	-2.25-34.40
No collateral branch (n = 108)	0.368	0.135	< 0.001	-13.88-19.07	0.263	0.069	0.006	-13.41-24.95
Total (n = 134)	0.270	0.073	0.002	-23.64-13.99	0.201	0.040	0.020	-28.35-12.80

LoA: Limits of agreement; WHVP: Wedged hepatic venous pressure; PVP: Portal venous pressure; HVPG: Hepatic venous pressure gradient; PPG: Portal venous pressure gradient.