Associate factors for endoscopic submucosal dissection operation time and postoperative delayed hemorrhage of early gastric cancer

Table 1 Single-factor analysis of endoscopic submucosal dissection operation time

Factors	n	Operation time (min) (mean ± SD)	r/t/F	P value
Age (yr)	520	66.78 ± 40.89	0. 191	0.812
Sex			0.311	0.764
Male	367	64.19 ± 41.21
Female	153	73.38 ± 35.82
Underlying diseases			0.921	0.146
None	379	63.11 ± 27.17
Hypertension	126	70.91 ± 32.19
Diabetes	12	67.24 ± 41.65
Cirrhosis	3	78.55 ± 30.52
History of taking anticoagulant or antiplatelet drugs			1.260	0.262
Yes	31	59.51 ± 48.44
No	489	66.12 ± 20.38
Lesion location			1.333	0.198
Upper gastric body	112	75.76 ± 31.76
Middle gastric body	70	63.36 ± 38.91
Lower gastric body	338	65.54 ± 39.18
Maximum diameter of lesion			8.691	< 0.001
< 3.00 cm	351	52.22 ± 29.81
≥ 3.00 cm	169	90.38 ± 40.21
Lesion form			11.123	< 0.001
Uplift type	134	48.54 ± 28.11
Flat type	138	53.66 ± 31.81
Concave type	91	71.17 ± 33.71
Mixed type	157	109.33 ± 40.28
Combined ulcer or scar			7.288	0.001
Yes	64	93.17 ± 37.34
No	456	62.36 ± 31.97
Combined perforation			9.327	< 0.001
Yes	21	121.33 ± 41.19
No	499	63.17 ± 36.85
Infiltrative depth			5.442	0.017
Mucosa	397	55.44 ± 36.18
Submucosa	123	87.23 ± 39.67

Table 2 Indigenous test results of multivariate linear regression independent variables

Factors	Unstandardized β value	Sx value	Standardized β value	t value	P value
Intercept	21.674	0.433	-	36.188	< 0.001
Maximum diameter of lesion	8.815	0.684	0.732	3.812	< 0.001
Lesion form - flat	1.277	1.475	0.032	0.333	0.493
Lesion form - concave type	3.766	0.872	0.383	4.456	< 0.001
Lesion form - mixed	10.247	0.929	0.633	9.580	< 0.001
Combined ulcer or scar	4.417	0.305	0.180	3.154	0.007
Combined perforation	3.692	2.303	0.153	2.340	0.020
Infiltrative depth - submucosa	2.536	0.569	0.077	2.652	0.008

Table 3 Single-factor analysis of the bleeding group and non-bleeding group

Factors	Bleeding group (n = 43)	Non-bleeding (n = 477)	χ2 value	P value
Age (yr)			0.120	0.729
< 60	23	242
≥ 60	20	235
Sex			0.015	0.903
Male	30	337
Female	13	140
Underlying diseases
Hypertension	16	110	4.301	0.038
Diabetes	2	10	1.142	0.285
Cirrhosis	0	3	-	-
History of taking anticoagulant or antiplatelet drugs			59.148	< 0.001
Yes	14	17
No	29	460
Lesion location			0.489	0.783
Upper gastric body	10	102
Middle gastric body	7	63
Lower gastric body	26	312
Maximum diameter of lesion			29.677	< 0.001
< 3.00 cm	13	338
≥ 3.00 cm	30	139
Lesion form			11.098	0.011
Uplift type	7	127
Flat type	12	126
Concave type	15	76
Mixed type	9	148
Combined ulcer or scar			0.020	0.887
Yes	5	59
No	38	418
Combined perforation			1.044	0.307
Yes	3	18
No	40	459
Infiltrative depth			3.274	0.070
Mucosa	28	369
Submucosa	15	108
ESD operation time			6.979	0.008
< 60 min	16	277
≥ 60 min	27	200

ESD: Endoscopic submucosal dissection.

Table 4 Logistic regression analysis of delayed hemorrhage after endoscopic submucosal dissection

Factors	β	Sx	Wald value	OR (95%CI)	P value
Hypertension
No				1
Yes	0.776	0.522	2.175	2.137 (0.912-2.643)	0.136
Taking anticoagulants
No
Yes	1.841	1.062	2.851	4.377 (0.657-37.912)	0.078
Maximum diameter of lesion
< 3.00 cm				1
≥ 3.00 cm	0.941	0.347	7.399	3.785 (1.165-4.277)	0.011
Lesion form
Uplift type				1
Flat type	0.701	1.031	0.452	2.011 (0.251-15.664)	0.072
Concave type	2.378	1.679	4.917	10.585 (2.133-35.381)	0.007
Mixed type	1.327	1.720	0.873	2.816 (0.463-19.832)	0.254
ESD operation time
< 60 min				1
≥ 60 min	1.446	1.271	3.541	2.958 (1.117-3.526)	0.011

ESD: Endoscopic submucosal dissection.