Model established based on blood markers predicts overall survival in patients after radical resection of types II and III adenocarcinoma of the esophagogastric junction

Table 1 Characteristics of the recruited patients

Characteristic	Surviving	Dead
Gender
Male	148 (78.3)	134 (80.7)
Female	41 (21.7)	32 (19.3)
Age (yr)	65.00 (60.00-71.00)	63.00 (59.00-69.25)
Tumor size	5.00 (4.00-7.00)	4.00 (2.50-5.50)
TNM stage
I-II	49 (25.9)	105 (63.3)
III	140 (74.1)	61 (36.7)
Differentiation grade
Low	59 (31.2)	70 (42.2)
High	130 (68.8)	96 (57.8)
BMI (kg/m2)	21.23 (19.88-23.85)	22.96 (20.96-25.00)
Tumor location
Siewert II	104 (55.0)	98 (59.0)
Siewert III	85 (45.0)	68 (41.0)
NLR	2.37 (1.61-3.62)	2.20 (1.55-2.86)
PLR	122.75 (87.98-182.94)	108.03 (81.43-152.54)
CEA	3.60 (1.95-9.30)	2.20 (1.44-6.85)
CA199	10.34 (5.64-20.26)	9.88 (5.75-16.88)
PNI	48.80 (45.30-53.15)	50.35 (47.20-53.45)
Albumin	41.60 (38.40-44.80)	42.40 (39.48-44.30)
Prealbumin	187.00 (153.50-234.00)	239.50 (201.75-264.25)
Neutrophil count	3.41 (2.72-4.53)	3.26 (2.38-4.48)
Platelet count	188.00 (143.00-235.50)	176.00 (145.00-219.50)
Lymphocyte count	1.43 (1.10-1.82)	1.63 (1.26-1.97)

Categorical values are expressed as number (percentage), and continuous variable are expressed as median (25^th percentile and 75^th percentile). NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; BMI: Body mass index; PNI: Prognostic nutritional index; CEA: Carcinoembryonic antigen.

Table 2 Univariate analysis of adenocarcinoma of the esophagogastric junction (types II and III) patients

Characteristic	Coefficient	HR (95%CI)	P value
Gender (men/women as reference)	0.078	1.081 (0.765, 1.528)	0.660
Age	0.019	1.019 (1.002, 1.037)	0.031
NLR	0.176	1.193 (1.112, 1.280)	< 0.001
Tumor size	0.178	1.195 (1.134, 1.260)	< 0.001
TNM stage	1.042	2.836 (2.046, 3.930)	< 0.001
Histologic type	0.390	1.477 (1.086, 2.009)	0.013
CA199	0.000	1.000 (0.998, 1.002)	0.948
PNI	-0.034	0.966 (0.940, 0.993)	0.013
PLR	0.003	1.003 (1.001, 1.005)	0.009
Fibrinogen	0.010	1.030 (0.970, 1.095)	0.332
Albumin	-0.289	0.557 (0.479, 1.008)	0.056
Prealbumin	-0.102	0.362 (0.271, 0.484)	< 0.001
Surgery time	0.017	1.017 (0.755, 1.369)	0.912
BMI	-0.580	0.560 (0.431, 0.727)	< 0.001
Cancerous node	0.219	1.245 (1.150, 1.347)	< 0.001
Hemoglobin	-0.006	0.994 (0.988, 1.000)	0.033
Tumor location	0.719	1.127 (0.855, 1.487)	0.397
Smoking	0.006	0.994 (0.970, 1.019)	0.624
Comorbidities	0.017	0.983 (0.953, 1.013)	0.264

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; BMI: Body mass index; PNI: Prognostic nutritional index; CEA: Carcinoembryonic antigen.

Table 3 Multivariate analysis of adenocarcinoma of the esophagogastric junction (types II and III) patients

Characteristic	Coefficient	HR (95%CI)	P value
TNM stage	0.827	2.286 (1.236, 4.227)	0.008
BMI	-0.470	0.625 (0.413, 0.946)	0.026
NLR	1.092	2.979 (1.565, 5.674)	0.001
CEA	0.008	1.008 (0.997, 1.019)	0.143
Age	0.031	0.970 (0.556, 1.691)	0.914
Tumor size	0.143	1.154 (0.651, 2.045)	0.624
PNI	0.347	1.415 (0.783, 2.557)	0.250
PLR	0.040	1.041 (0.567, 1.912)	0.897
Hemoglobin	0.197	0.821 (0.479, 1.408)	0.474
Prealbumin	0.122	0.885 (0.496, 1.578)	0.678
Differentiation grade	0.073	1.075 ( 0.630, 1.836)	0.791
Cancerous node	0.084	1.088 (0.587, 2.016)	0.789

NLR: neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; BMI: Body mass index; PNI: Prognostic nutritional index; CEA: Carcinoembryonic antigen.

Table 4 Nomogram scoring system

NLR	Points	TNM stage	Points	BMI	Points
Low (1)	0	I and II (1)	0	Low (1)	0
High (2)	26	III and IV (2)	20	Normal (2)	58
				High (3)	100

NLR: Neutrophil-to-lymphocyte ratio; BMI: Body mass index.