Copyright
        ©The Author(s) 2022.
    
    
        World J Gastrointest Surg. May 27, 2022; 14(5): 397-408
Published online May 27, 2022. doi: 10.4240/wjgs.v14.i5.397
Published online May 27, 2022. doi: 10.4240/wjgs.v14.i5.397
            Table 1 Classification for gastroenteropancreatic neuroendocrine neoplasms by World Health Organization
        
    | Terminology | Differentiation | Grade | Ki67 index, % | Mitotic count, 2 mm2 | 
| NET, G1 | Well differentiated | Low | < 3 | < 2 | 
| NET, G2 | Well differentiated | Intermediate | 3–20 | 2–20 | 
| NET, G3 | Well differentiated | High | > 20 | > 20 | 
| NEC, G3 | Poorly differentiated | High | > 20 | > 20 | 
            Table 2 Milan neuroendocrine neoplasms criteria
        
    | Milan selection criteria of GEP-NEN LM | |
| 1 | Low grade NEN | 
| 2 | Portal drainage of the primary tumor with complete resection of extrahepatic disease | 
| 3 | Liver involvement < 50% | 
| 4 | Duration of stable disease over 6 mo | 
| 5 | Age < 60 yr (relative criteria) | 
- Citation: Que QY, Zhang LC, Bao JQ, Ling SB, Xu X. Role of surgical treatments in high-grade or advanced gastroenteropancreatic neuroendocrine neoplasms. World J Gastrointest Surg 2022; 14(5): 397-408
 - URL: https://www.wjgnet.com/1948-9366/full/v14/i5/397.htm
 - DOI: https://dx.doi.org/10.4240/wjgs.v14.i5.397
 
