Copyright
©The Author(s) 2021.
World J Gastrointest Surg. Sep 27, 2021; 13(9): 1012-1024
Published online Sep 27, 2021. doi: 10.4240/wjgs.v13.i9.1012
Published online Sep 27, 2021. doi: 10.4240/wjgs.v13.i9.1012
Table 1 Demographic and clinical characteristics of participants according to surveillance intensity (n = 1888)
Variables | Surveillance intensity | P value | |
Lower intensity (n = 1024) | Higher intensity (n = 864) | ||
Age, mean (IQR) | 60.0 (52.0–68.0) | 58.0 (50.3–67.0) | 0.178 |
Gender, n (%) | 0.502 | ||
Male | 607 (59.3) | 528 (61.1) | |
Female | 417 (40.7) | 336 (38.9) | |
Cancer site, n (%) | 0.795 | ||
Colon | 365 (35.6) | 303 (35.1) | |
Rectum | 659 (64.4) | 561 (64.9) | |
Differentiation, n (%) | 0.027 | ||
WD/MD | 945 (92.3) | 781 (90.4) | |
PD/SRC/MUC | 72 (7.0) | 82 (9.5) | |
Unknown | 7 (0.7) | 1 (0.1) | |
Total lymph nodes, n (%) | 0.001 | ||
< 12 | 129 (12.6) | 49 (5.7) | |
≥ 12 | 895 (87.4) | 815 (94.3) | |
(y) pT, n (%) | 0.002 | ||
0 | 12 (1.2) | 6 (0.7) | |
1 | 66 (6.4) | 36 (4.2) | |
2 | 126 (12.3) | 89 (10.3) | |
3 | 770 (75.2) | 660 (76.4) | |
4 | 50 (4.9) | 73 (8.4) | |
(y) pN, n (%) | 0.010 | ||
1c | 14 (1.4) | 8 (0.9) | |
1 | 735 (71.8) | 570 (66.0) | |
2 | 275 (26.8) | 286 (33.1) | |
Perineural invasion, n (%) | 219 (21.4) | 262 (30.3) | < 0.001 |
Lymphovascular invasion, n (%) | 371 (36.2) | 344 (39.8) | 0.110 |
Resection margin, n (%) | 0.004 | ||
Positive | 18 (1.7) | 41 (4.7) | |
Unknown | 7 (0.7) | 8 (0.9) | |
APCT, mean ± SD | 1.49 ± 0.47 | 2.67 ± 1.31 | < 0.001 |
CCT, mean ± SD | 0.62 ± 0.41 | 1.48 ± 0.91 | < 0.001 |
Total imaging studies, mean ± SD | 2.11 ± 0.58 | 4.14 ± 1.64 | < 0.001 |
Table 2 Factors affecting overall survival of participants
Factors | Univariate | Multivariate | ||
OR (95%CI) | P value | OR (95%CI) | P value | |
Age (yr) | 1.027 (1.019–1.035) | < 0.001 | 1.031 (1.023–1.039) | < 0.001 |
Sex | 0.704 (0.592–0.836) | < 0.001 | 0.711 (0.598–0.845) | < 0.001 |
Surveillance intensity | 1.650 (1.400–1.945) | < 0.001 | 1.531 (1.295–1.808) | < 0.001 |
Differentiation | ||||
WD/MD | Ref. | Ref. | ||
PD/SRC/MUC | 1.832 (1.424–2.356) | < 0.001 | 1.660 (1.285–2.143) | < 0.001 |
(y) pT stage | ||||
0–2 | Ref. | Ref. | ||
3–4 | 1.937 (1.491–2.516) | < 0.001 | 1.461 (1.111–1.921) | 0.007 |
(y) pN stage | ||||
1c | Ref. | Ref. | ||
1 | 5.136 (0.721–36.571) | 0.102 | 4.754 (0.667–33.906) | 0.12 |
2 | 9.322 (1.308–66.457) | 0.026 | 7.067 (0.988–50.556) | 0.051 |
Lymphovascular invasion | 1.607 (1.365–1.891) | < 0.001 | 1.256 (1.057–1.491) | 0.01 |
Perineural invasion | 1.818 (1.535–2.154) | < 0.001 | 1.466 (1.224–1.755) | < 0.001 |
Resection margin1 | 1.972 (1.360–2.860) | < 0.001 | 1.603 (1.097–2.341) | 0.015 |
Table 3 Factors affecting recurrence-free interval of participants
Factors | Univariate | Multivariate | ||
OR (95%CI) | P value | OR (95%CI) | P value | |
Age (yr) | 0.995 (0.987–1.002) | 0.165 | 0.999 (0.991–1.006) | 0.715 |
Sex | 0.907 (0.765–1.076) | 0.262 | ||
Surveillance intensity | 2.218 (1.870–2.632) | < 0.001 | 1.999 (1.680–2.377) | < 0.001 |
Differentiation | ||||
WD/MD | Ref. | Ref. | ||
PD/SRC/MUC | 1.507 (1.151–1.974) | 0.003 | 1.287 (0.979–1.694) | 0.071 |
(y) pT stage | ||||
0–2 | Ref. | Ref. | ||
3–4 | 2.118 (1.610–2.785) | < 0.001 | 1.596 (1.197–2.127) | 0.001 |
(y) pN stage | ||||
1c | Ref. | Ref. | ||
1 | 2.737 (0.682–10.989) | 0.156 | 2.501 (0.621–10.063) | 0.197 |
2 | 5.260 (1.308–21.156) | 0.019 | 3.813 (0.943–15.413) | 0.060 |
Lymphovascular invasion | 1.460 (1.236–1.724) | < 0.001 | 1.143 (0.957–1.364) | 0.140 |
Perineural invasion | 1.949 (1.641–2.313) | < 0.001 | 1.431 (1.192–1.719) | < 0.001 |
Resection margin1 | 2.192 (1.529–3.144) | < 0.001 | 1.565 (1.083–2.262) | 0.017 |
Table 4 Factors affecting post-recurrence survival of participants
Factors | Univariate | Multivariate | ||
OR (95%CI) | P value | OR (95%CI) | P value | |
Age (yr) | 1.015 (1.007–1.024) | < 0.001 | 1.015 (1.006–1.024) | 0.001 |
Sex | 0.824 (0.676–1.004) | 0.054 | 0.842 (0.688–1.032) | 0.098 |
Image intensity | 0.971 (0.799–1.179) | 0.767 | ||
Differentiation | ||||
WD/MD | Ref. | Ref. | ||
PD/SRC/MUC | 2.632 (1.779–3.137) | < 0.001 | 2.072 (1.553–2.766) | < 0.001 |
(y) pT stage | ||||
0–2 | Ref. | |||
3–4 | 1.146 (0.833–1.576) | 0.401 | ||
(y) pN stage | ||||
1c | Ref. | |||
1 | 2.139 (0.300–15.256) | 0.448 | ||
2 | 3.363 (0.471–24.009) | 0.226 | ||
Lymphovascular invasion | 1.456 (1.204–1.760) | < 0.001 | 1.152 (0.940–1.412) | 0.174 |
Perineural invasion | 1.384 (1.141–1.677) | 0.001 | 1.284 (1.045–1.579) | 0.018 |
Resection margin1 | 1.416 (0.966–2.075) | 0.075 | 1.266 (0.856–1.871) | 0.237 |
Curative resection | 0.296 (0.229–0.381) | < 0.001 | 0.331 (0.255–0.428) | < 0.001 |
- Citation: Park MY, Park IJ, Ryu HS, Jung J, Kim M, Lim SB, Yu CS, Kim JC. Optimal postoperative surveillance strategies for stage III colorectal cancer. World J Gastrointest Surg 2021; 13(9): 1012-1024
- URL: https://www.wjgnet.com/1948-9366/full/v13/i9/1012.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v13.i9.1012