Case Report Open Access
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World J Gastrointest Surg. Apr 27, 2025; 17(4): 104102
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.104102
Type III choledochal cyst confirmed by aspiration and treated with endoscopic fenestration plus internal drainage: A case report
Zi-Meng Wang, School of Medicine, Nankai University, Tianjin 300071, China
Zi-Meng Wang, Song Su, En-Qiang Ling-Hu, Ning-Li Chai, Department of Gastroenterology, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, China
ORCID number: Zi-Meng Wang (0009-0001-1050-4857); En-Qiang Ling-Hu (0000-0003-4506-7877); Ning-Li Chai (0000-0002-6791-5817).
Author contributions: Wang ZM and Su S were directly involved in patient care, collected the data and drafted the manuscript; Chai NL performed the endoscopic diagnosis and treatment procedures; Ling-Hu EQ supervised the treatment and critically revised the manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ning-Li Chai, MD, Chief Physician, Professor, Department of Gastroenterology, The First Medical Center of Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. chainingli@vip.163.com
Received: December 16, 2024
Revised: January 12, 2025
Accepted: February 17, 2025
Published online: April 27, 2025
Processing time: 106 Days and 0.2 Hours

Abstract
BACKGROUND

Type III choledochal cysts (CCs) are extremely rare, and they present as dilatations and herniations of the end of the common bile duct into the duodenum. Moreover, type II CCs may be easily misdiagnosed as intraduodenal polyps or tumors. Thus, adequate differential diagnosis and selection of appropriate treatment are important.

CASE SUMMARY

A young man with a duodenal mass presented with 3-year intermittent abdominal pain and acute pancreatitis 3 days before hospitalization. After evaluation by magnetic resonance imaging and endoscopic ultrasonography, the duodenal papilla was pressed, and the bile flowed out slowly, which was speculated to be the cause of his symptoms. The lesion was punctured with a submucosal injection needle, and golden clear fluid was aspirated. Laboratory tests of the aspirate after 50-fold dilution revealed significantly elevated total bilirubin, direct bilirubin, amylase and lipase. Taken together, these findings confirmed that the lesion was a type III CC. The patient underwent fused surgical procedures. Fenestration plus internal drainage of the lesion was subsequently performed with a DualKnife. After drainage, the incision was sealed with tissue clips. During follow-up, the patient recovered well, and no abdominal pain symptoms or acute pancreatitis recurred.

CONCLUSION

Laboratory tests of cyst aspirates are beneficial for diagnosis, and endoscopic fenestration plus internal drainage works well to mitigate cysts.

Key Words: Choledochal cyst; Aspiration; Drainage; Endoscopic ultrasound; Magnetic resonance imaging; Case report

Core Tip: In adults with duodenal masses, the possibility of choledochal cysts should be considered. Endoscopic puncture and laboratory examination of aspirates can effectively assist in clarifying the diagnosis. For patients who refuse surgical treatment, endoscopic fenestration plus drainage is a safe, minimally invasive option that provides effective symptomatic relief. Furthermore, long-term periodic follow-up and monitoring utilizing serological tests and imaging are essential.



INTRODUCTION

Choledochal cysts (CCs) are congenital cystic dilatations of the biliary tree[1]. Most CCs are diagnosed in childhood, with only 25% of CCs identified in adults. The incidence of CCs is 1:100000-150000 in Western populations, and the incidence of CCs is higher in Asian populations, with an incidence of 1:1000[2,3]. The exact cause of CCs remains unknown. Todani classification is the most widely used classification for CCs[4]. Type I CCs are the most common type, followed by type IV CCs[5]. Type III CCs are rare in both the children and adult population but occur more frequently in adults[6]. Surgical resection is the mainstay of treatment for CCs. The present case report emphasizes the comprehensive differential diagnosis of CCs by combining laboratory tests and imaging, and it introduces an option for treatment when the patient refuses surgery.

CASE PRESENTATION
Chief complaints

A 19-year-old Chinese man was referred to gastroenterology at our center with the complaint of intermittent abdominal pain for 3 years, with aggravated pain for 3 days prior to hospitalization.

History of present illness

The patient had intermittent abdominal pain with no apparent cause 3 years prior, which occurred every 1-2 months. The cause of the abdominal pain was unclear because there was no further diagnosis or treatment. The patient’s abdominal pain worsened 3 days prior, mimicking colic symptoms. Laboratory tests revealed a lipase level of 2551.6 U/L (reference range: 13-60 U/L) and an amylase level of 720.1 U/L (reference range: 0-150 U/L). Abdominal computed tomography (CT) revealed pancreatic swelling, suggesting the possibility of pancreatitis. Abdominal ultrasound and CT did not reveal obvious biliary tract structural abnormalities or bile duct stones. The patient was initially diagnosed with acute pancreatitis (AP) at the local hospital, and his symptoms were relieved after early treatment with ulinastatin, octreotide acetate, and omeprazole. The patient was referred to our department for further etiologic diagnosis.

History of past illness

The patient’s blood lipids were normal in previous examinations. The patient denied any other history of disease.

Personal and family history

The patient had no history of alcohol consumption. No significant family history was reported.

Physical examination

Physical examination revealed abdominal tenderness without rebound tenderness, and no abdominal masses were detected.

Laboratory examinations

Laboratory tests revealed a lipase level of 232.5 U/L (reference range: 13-60 U/L) and an amylase level of 196.5 U/L (reference range: 0-150 U/L). Liver and kidney function tests and tumor marker analysis revealed normal results. Analysis of immunoglobulin G (IgG) levels showed an IgG4 level of 248.0 mg/dL (reference range: 3-201 mg/dL) and an IgG1 level of 1030.0 mg/dL (reference range: 405-1011 mg/dL). Because the IgG4 and IgG1 levels were not significantly elevated, there was little likelihood of autoimmune pancreatitis.

Imaging examinations

Magnetic resonance imaging (MRI) revealed a duodenal cyst, and no abnormal stenosis or dilatation of the bile duct or pancreatic duct was observed (Figure 1A). Endoscopy revealed a cystic mass in the descending part of the duodenum with a smooth surface and a short diameter of approximately 3 cm (Figure 1B). The lesion had a soft texture. Endoscopic ultrasonography (EUS) revealed a homogeneous hypoecho without blood flow inside the lesion (Figure 1C). After careful evaluation, the duodenal papilla was pressed, and the bile flowed out slowly (Figure 1D), which was speculated to be the cause for his symptoms and AP onset. Subsequently, the lesion was punctured with a submucosal injection needle, and golden clear fluid was aspirated (Figure 2A). Dilute the aspirate 50-fold using a sample diluent of 0.9% sodium chloride. Laboratory tests of the 50-fold diluted aspirate revealed a total bilirubin level of 329.4 μmol/L (reference 0-21 μmol/L), a direct bilirubin level of 243.3 μmol/L (reference 0-21 μmol/L), an amylase level > 59605 U/L (reference 0-150 U/L), and a lipase level > 15000 U/L (reference 13-60 U/L), representing significantly elevated levels. Taken together, these findings confirmed that the lesion was a type III CC.

Figure 1
Figure 1 Imaging of the patient prior to treatment. A: Magnetic resonance imaging revealed a duodenal cyst with normal bile and pancreatic ducts; B: Endoscopy revealed a cystic mass in the descending part of the duodenum; C: Endoscopic ultrasonography revealed a homogeneous hypoecho without blood flow; D: The duodenal papilla was pressed, and the bile flowed out under endoscopy. BD: Bile duct; PD: Pancreatic ducts.
Figure 2
Figure 2 Images during patient treatment and follow-up. A: Clear yellow liquid was aspirated from the cyst; B: Fenestration of the mucosa; C: Closure of the incision with tissue clips; D: Gastroduodenoscopy showed good recovery without recurrence three months after treatment.
FINAL DIAGNOSIS

The lesion was diagnosed as a type III CC.

TREATMENT

The patient was fully informed of the treatment and risks involved with the surgery. Given the high risk and trauma of the surgery, the patient refused to undergo surgical treatment. Therefore, fenestration plus internal drainage of the lesion was performed using a DualKnife (Figure 2B). Yellow clear fluid was withdrawn after fenestration, and the inner surface of the cystic cavity was smooth. The lesion was subsequently squeezed repeatedly, and the lesion collapsed after the cystic fluid was extruded. After drainage, the incision was sealed with tissue clips (Figure 2C).

OUTCOME AND FOLLOW-UP

Post-treatment review showed a lipase level of 25.7 U/L (reference range: 13-60 U/L) and an amylase level of 74.9 U/L (reference range: 0-150 U/L). During follow-up, the patient recovered well, and no abdominal pain symptoms or AP recurred. Gastroduodenoscopy revealed no recurrence at three months after treatment (Figure 2D).

DISCUSSION

CCs are mostly congenital and more common in children. Approximately two-thirds of CCs present at age 10, but this disease can occur at all ages[7]. Although jaundice is common in early childhood, abdominal pain is a major symptom in adolescents and adults[8], as shown in the present case. Notably, such nonspecific symptoms, to some extent, lead to delayed diagnosis. In the present case, the patient presented with intermittent nonspecific abdominal pain for 3 years without other gastrointestinal symptoms, during which the patient was not well examined nor definitively diagnosed. The patient was definitively diagnosed and etiologically treated only when the disease induced AP.

Abdominal ultrasound and CT can be used as preliminary tests to screen for abnormal biliary structures and bile duct stones[9]. However, these tests fail to identify the presence of anomalous pancreaticobiliary junctions[10]. MRI can show the location and morphology of the cyst well. EUS provides a safe and reliable examination method to explore the condition of the bile ducts and to make a differential diagnosis of the cystic nature. Notably, magnetic resonance cholangiopancreatography examination was not prioritized in the present case because the initial abdominal ultrasound and CT missed the identification of CCs. Laboratory tests were performed on aspirates from the cysts, which showed markedly elevated pancreatic enzymes and bilirubin, further clarifying the diagnosis. The supplemental laboratory tests offered new ideas for clinical diagnosis.

Treatment depends on the type of CC. Therapy for types Ι and IV CCs requires complete resection of the choledochus and restoration of bile flow, whereas the strategy for type II CCs includes simple cystectomy or diverticulectomy. Type III CCs can be treated with sphincterotomy or complete resection[11]. When a patient refuses surgical intervention, endoscopic fenestration plus internal drainage is an alternative and cost-effective option, providing a simple, less invasive and reproducible treatment. CCs are usually diagnosed and treated via surgery. However, the present patient was diagnosed with a CC via endoscopic aspiration. CC is often associated with pancreaticobiliary malunion, forming a common channel that typically has cystic fluid. To the best of our knowledge, the present case report is the first to provide laboratory results on the aspirate of a type III CC. Despite the low risk of transformation of type III cysts into malignant tumors, long-term follow-up with biochemical evaluation and abdominal ultrasound is suggested for optimal prognosis.

CONCLUSION

In summary, the possibility of a CC should be considered for duodenal masses, even in adults. MRI and EUS are helpful for diagnosis, while endoscopic aspiration and laboratory tests can confirm the diagnosis. Although surgical resection is the main treatment for CCs, endoscopic fenestration plus drainage could be an alternative treatment option for patients who refuse surgery.

Footnotes

Provenance and peer review: Unsolicited article; Externally peer reviewed.

Peer-review model: Single blind

Specialty type: Gastroenterology and hepatology

Country of origin: China

Peer-review report’s classification

Scientific Quality: Grade C

Novelty: Grade B

Creativity or Innovation: Grade B

Scientific Significance: Grade B

P-Reviewer: Xing X S-Editor: Wei YF L-Editor: A P-Editor: Zhang L

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