Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy: A case report

Figure 1 Timeline of history of past illnessthe, initial diagnosis, surgical intervention, postoperative adjuvant therapy, and follow-up period. PET-CT: Positron emission tomography/computed tomography; PD-1: programmed cell death 1.

Figure 2 Positron emission tomography/computed tomography showing high accumulation of ¹⁸F-fludeoxyglucose in the gastric cardia region. A maximum standardized uptake value of 20.03.

Figure 3 Upper endoscopy and surgical resection. A: The presence of a large mass of about 5 cm × 4 cm at the stomach fundus was confirmed by upper endoscopy; B: Surgical resection of the tumor revealed a large mass located in the stomach fundus near the cardia, showing a type of ulcer infiltrate measuring 6 cm × 5 cm.

Figure 4 Hematoxylin and eosin staining and in situ hybridization. A: Histopathological examination of a stomach tumor section by hematoxylin and eosin staining, showing poorly differentiated carcinoma with prominent lymphoplasmacytic infiltration; B: In situ hybridization analysis showing positive staining for Epstein-Barr virus-encoded RNA.