Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

Figure 1 Comparison of the estimated glomerular filtration rate before and after hepatocellular carcinoma resection in patients with stage 4 or 5 chronic kidney disease. In patients with stage 4 or 5 chronic kidney disease who did not require maintenance hemodialysis, the estimated glomerular filtration rate (EGFR) values did not decrease after the operation (n = 13). Furthermore, no patient received maintenance hemodialysis after the operation. The EGFR values were measured before and one month after hepatectomy. CKD: Chronic kidney disease; EGFR: Estimated glomerular filtration rate.

Figure 2 Overall survival and recurrence-free survival rates of patients with or without renal dysfunction. A: Overall survival (OS) was similar between the renal dysfunction (RD) and non-RD groups (P = 0.524); B: OS was also similar among the severe, mild, and control groups (P = 0.605); C: Recurrence-free survival (RFS) was similar between the RD and non-RD groups (P = 0.464); D: RFS was also similar among the severe, mild, and control groups (P = 0.762). RD: Renal dysfunction.

Figure 3 Overall survival and recurrence-free survival rates of patients with renal dysfunction after propensity score matching. A: The median survival time was 76.5 mo in patients with renal dysfunction (RD) and 73.0 mo in patients without RD, so overall survival was similar between the RD and non-RD groups (P = 0.343) after propensity score matching (PSM); B: Recurrence-free survival also did not differ significantly between the RD and non-RD groups after PSM (P = 0.314) after PSM. RD: Renal dysfunction.

Figure 4 Overall survival rates of patients with renal dysfunction. A: Overall survival (OS) rates of patients with renal dysfunction (RD) Child-Pugh grade A disease. The OS rate was similar between the RD (n = 124) and non-RD (n = 649) hepatocellular carcinoma (HCC) patients with Child-Pugh grade A disease (P = 0.489); B: OS rates of patients with RD who died from only HCC. The OS rate was similar between the RD (n = 114) and non-RD (n = 616) HCC patients who died from only HCC (P = 0.993).